所以,找到能区分抗 NMDA 受体脑炎和其他精神疾病的特殊精神症状,就成了医学研究的当务之急。 为了攻克这个难题,来自大阪红十字医院的研究人员在《BMC Neurology》期刊上发表了一篇名为《Time distortion as a characteristic symptom in the early stages of anti - NMDA receptor encephalitis: two case reports》的论...
NMDA receptor antibody related encephalitisIrani, SR
四川大学华西医院神经内科/脑科学与类脑研究院洪桢团队于2024年2月在Brain Behavior and Immunity发表文章“Intestinal dysbiosis exacerbates susceptibility to the anti-NMDA receptor encephalitis-like phenotype by changing blood brain barrier...
The etiology and pathogenesis of “anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis” and the role of autoantibodies (AB) in this condition are still obscure. While NMDAR1-AB exert NMDAR-antagonistic properties by receptor internalization, no firm
抗NMDA 受体脑炎是一种自身免疫性脑炎,在2007年于此类病人体内发现了抗 N-甲基-D-天冬氨酸受体(N-methyl-D-aspartatereceptor-NMDA)抗体,并提出了抗 NMDA 受体脑炎的诊断,具体病因及发病机制尚不明确。NMDA 受体是一种分布于海马、前额皮质离子型谷氨酸受体,属于突触后膜的阳离子通道,与学习、记忆和精神行为密切相...
Methods We present a case of anti-NMDA receptor encephalitis in a patient with autism spectrum disorder. "OP" is a 16-year-old male with a history of attention-deficit/ hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) who presented with a 3-day history of acute-onset ...
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an anti-neuronal antibody-mediated inflammatory brain disease that causes severe psychiatric and neurological deficits in previously healthy patients. The aims of this study were to demonstrate the clinical characteristics of patients diagnosed with...
Anti-NMDA-receptor encephalitis: A reviewAnti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis, often mistaken for viral infection, presents a bewildering mix of behavioral, psychiatric, movement, speech, autonomic,...
目前自身免疫性脑炎(autoimmune encephalitis,AE)患病比例占脑炎病例的10%～20%,以抗N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)脑炎最常见,约占AE患者的80%,而抗α-氨基-3-羟基-5-甲基-4-异唑丙酸受体(anti-...
异常EEG或头MRI可以辅助医生诊疗,尽管不能明确,但当存在异常时,应该进行NMDA受体抗体的检测。进一步的前瞻性研究应该包括对精神症状的仔细评估。 原文:Warren N, Siskind D, O'GormanC. Refining the psychiatric syndrome of anti-N-methyl-d-aspartate receptorencephalitis[J...