Hoopmann M, Valter M, Schmidt T, Warm M, Kurbacher C, Mallmann P . Combined life-threatening hematological and non-hematological toxicity in a patient treated with capecitabine for metastatic breast cancer (German) . Geburtshilfe Frauenheilk ( 2003 ); 63 : 883 ....
receive chemotherapy on day 1 and day 8 were also similar across included trials: neutrophil count ≥1.5 × 109/L (≥2.0 × 109/L in MILES2 and MILES3), platelets ≥100 × 109/L, hemoglobin ≥8 g/dL and no grade ≥ 2 non-hematological toxicity (excluding alopecia...
Mortality and acute toxicity were measured as a dichotomous outcome. Toxicity was scored according to CTCAE-4 version 4.03 in case of nonhematological toxicity grade ≥3 or radiation pneumonitis grade ≥2.5 TNM-7 was used in the database in 2015 and 2016. Since the introduction of the TNM-...
Most frequent toxicity was neutrocytopenia mainly due to docetaxel administration. As nonhematological grade 3 (G3) toxicities, appetite loss, neuropathy, active pulmonary infection, and interstitial lung disease (ILD) were reported. Any new safety signal was not detected comparing with previous ...
This hematological toxicity caused 20% of cycles 2 and 3 of ICE to be delayed until platelet count recovered to greater than 50,000/mm3. The median time to deliver three cycles of ICE was 38 days instead of the planned 31 days. In the initial treatment of DLCL, maintenance of dose ...
Hematological disease Acquired autoimmune protein S deficiency and secondary thrombophilia, which may be linked to NCPF/IPH and portal hypertension, have been reported in HIV patients [77]. NCPF/IPH has also been reported as a long-term complication of bone marrow transplant [57, 78, 79]. Other...
Do not start LYNPARZA until patients have recovered from hematological toxicity caused by previous chemotherapy (≤Grade 1). Monitor complete blood count for cytopenia at baseline and monthly thereafter for clinically ...
Non-hematological toxicities were relatively mild. Allergy (2%), skin rash (11%), edema (9%), and neuropathy (9%) occurred infrequently, and all were grade 1 toxicity. Of the 45 patients, 19 showed partial response, giving a response rate of 42%. The median survival time was 43.3 ...
Patients were required to have normal hematological indexes, qualified hepatic, renal, and pulmonary functions so that neoadjuvant therapy followed by radical resection could be tolerated. Based on PET/CT and chest CT at diagnostic time, patients were divided into resectable and potentially resectable ...
Anemia was the primary hematological toxicity and observed in 7 (17.1%) patients. Five patients experienced grade 3/4 anemia. Four patients (9.8%) experienced grade 3/4 febrile neutropenia and grade 3/4 thrombocytopenia, respectively. Nonhematological toxicities were mild to moderate in intensity. ...