However, concerns regarding rare but serious long-term toxicities including cardiotoxicity and hematologic malignancies have driven interest in alternative adjuvant therapy options with more favorable toxicity
In all of these studies, we see the toxicity profile that we see with checkpoint inhibitors in solid tumors, with a lot of inflammatory autoimmune-type reactions that are usually manageable. And what’s really exciting, it offers us a new platform to develop more in hematologic malignancies in...
Bardai A, Lamberts RJ, Blom MT, Spanjaart AM, Berdowski J, van der Staal SR, et al. Epilepsy is a risk factor for sudden cardiac arrest in the general population. PLoS ONE. 2012;7(8): e42749. ArticleCASPubMedPubMed CentralGoogle Scholar Kapur J, Elm J, Chamberlain JM, Barsan W...
It has Food and Drug Administration (FDA) approval for prophylaxis of invasive fungal infection in hematopoietic stem cell transplant recipients with graft-versus-host disease (GVHD) and patients with hematologic malignancies and prolonged neutropenia. It is also FDA approved for treatment of ...
3 Lenalidomide was active (overall response rate [ORR] 47%, complete remission [CR] 9%), although hematologic toxicity at grades 3 and 4 was significant, and 2 patients developed tumor lysis syndrome. Furthermore, 58% of patients experienced a unique tumor flare reaction, occurring within 24 ...
Yang TJ, Oh JH, Apte A et al (2014) Clinical and dosimetric predictors of acute hematologic toxicity in rectal cancer patients undergoing chemoradiotherapy. Radiother Oncol 113:29–34 Article PubMed PubMed Central Google Scholar Mell LK, Schomas DA, Salama JK et al (2008) Association between...
In contrast to Chimeric antigen receptor (CAR)-T, which is used mainly for hematologic malignancies, cancer antigens exposure on the cell surface in the TCR-T cell therapy is not necessary. Thus, it is being developed for solid tumors, which often lack targetable surface antigens. The ...
Acute toxicity is believed to be the result of calcium chelation, leading to activation of low-calcium voltage-gated channels in peripheral nerves.56 The dose-limiting neurotoxicity is the late onset, cumulative, sensory, symmetric distal axonal neuropathy. There is no motor i...
Considering that renal failure is associated with increased melphalan toxicity [27], studies recommend reducing the melphalan dose to 140 mg/m2 in patients with renal insufficiency [28, 29]. Another study involving MM patients with a cre- atinine clearance of 60 mL/min/1.73m2 or lower...
Abstract Immunomodulatory drugs (IMiDs) have become an integral part of therapy for both newly diagnosed and relapsed/refractory multiple myeloma (RRMM). IMiDs bind to cereblon, leading to the degradation of proteins involved in B-cell survival and proliferation. Thalidomide, a first-generation IMiD,...