the Ras-binding domain (RBD) in conserved region 1 (CR1), the negative regulatory domain (NRD) in CR2 and the protein kinase domain in CR3. We were unable to detect mRNA or to make cDNA, likely as a result of nonsense mediated decay68. The stop codon is in a similar location to the...
Computational predictions identified Ddx3x mRNA as a potential target of miR-183, miR-96 and miR-182, bearing two conserved miRNA-binding sites in the 30-untranslated repeat (UTR; 4 NATURE COMMUNICATIONS | 6:7305 | DOI: 10.1038/ncomms8305 | www.nature.com/naturecommunications & 2015 Macmillan...
Previously, other studies have used mice of the same age when comparing sex differences, meaning that the bigger male mice would likely receive a more severe aortic restriction in age-matched animals, resulting in more severe disease. Sham-operated mice underwent the same surgical procedure as TAC...
Even if the retinal cell population is post-mitotic, meaning that episomal non-viral vectors should be retained, integrase from bacteriophage ΦC31 has been demonstrated to confer genomic integration of plasmid DNA and long-term expression in mammalian cells, including RPE (Chalberg et al., 2005)...
For instance, we still do not know whether responses to high population densities are conserved across taxa or to what extent population density during development has carry-over effects to adulthood and offspring that mediate eco-evolutionary processes. As a result, we lack a generalised ...
In addition, conserved action of Atf1, a transcriptional activator, and Tup11-Tup12 corepressors along mlonRNA transcription mediated chromatin regulation is suggested. This idea provides new insight into the biological meaning of mlonRNAs found in various eukaryotes. 展开 ...
The proper functioning of any living cell relies on complex networks of gene regulation. These regulatory interactions are not static but respond to change
Thus, some vlincs are conserved in mouse at least in the syntenic locations. The fact that only 15 (or 13 if more stringent criteria above are used) vlincs are conserved in mouse is probably due to the fact that: (1) only 172 such regions were identified in FANTOM3, probably due to...
Novel lincRNA genes trend to have less exons than that of the known lincRNA genes (2.5 vs 2.8) and protein-coding genes (2.5 vs 7.8); (D) Representative images of conserved regions between pig lincRNAs with human and mouse lincRNAs. Thick lines indicate an exon and thin lines indicates...
that AS-NMD regulates the abundance of a wide variety of transcripts. One example is theSCN1Anon-productive AS event35in which the non-coding exon and flanking intronic sequences are 96% conserved between human and mouse (Supplementary Fig.8b). To confirm that the non-productive exon is ...