ProMiR is a web-based service for the prediction of potential microRNAs (miRNAs) in a query sequence of 60-150 nt, using a probabilistic colearning model. Identification of miRNAs requires a computational method to predict clustered and nonclustered, conserved and nonconserved miRNAs in various sp...
Using large-scale simulations, we have established that unique scaled microstructures exist in symmetric mixtures evolving via nonconserved and conserved dynamics. We characterize their morphologies by the interfacial shape distribution, a counterpart to the particle size distribution, and their topologies ...
Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection
The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved neutralizing epitope
Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' (identifying molecular function with high confidence) or as 'non-specific' (identifying ...
Next Generation Sequencing techniques are producing enormous amounts of biological sequence data and analysis becomes a major computational problem. Currently, most analysis, especially the identification of conserved regions, relies heavily on Multiple
Visualization of the distribution of protein families highlights the presence of 19 modules that are not only lineage specific but are also well conserved within each lineage (Fig.2). In fact, we identified such archaeal group-specific modules in 10 out of 11 non-DPANN with more than 10 genom...
The Drosophila gene embryonic lethal abnormal visual system (elav) is the prototype of a gene family present in all metazoans. Its members encode structurally conserved neuronal proteins with three RNA Recognition Motifs (RRM) but they paradoxically act
Cryptosporidiumspp. have only about 3900 protein-coding genes compared to the 5300 genes ofP.cf.gigantea. This result could be partially explained by the absence of certain non-coding sequences in the assemblies, such as centromeres, telomeres and repeated sequences which are difficult to sequence...
rare across non-decomposition environments and appear unique to the breakdown of terrestrial decaying flesh, including humans, swine, mice and cattle, with insects as likely important vectors for dispersal. The observed lockstep of microbial interactions further underlies a robust microbial forensic tool ...