必应词典为您提供non-codingsequence的释义,网络释义: 非编码序列;中非编码序列;非编码的顺序;
which is much lower than the 100% conservation over 200 bp used to define mammalian ultraconserved elements4. Nonetheless, the set of 2,012 most highly conserved noncoding sequences (with, at most, 0.5 substitutions per site over at least 50 bp;Supplementary...
Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection
More recently, the converging fields of bioinformatics, genomics, and next generation sequencing have accelerated discoveries in a number of classes of noncoding sequences, including transcription factor binding sites (TFBS), microRNA genes, and long noncoding RNA genes, each of which mediates ...
Therefore, accurate sequence-based prediction of chromatin features requires a flexible quantitative model capable of modeling such complex dependencies—and those predictions may then be used to estimate functional effects of noncoding variants.基于序列的,可以考虑到更多复杂的情况,这比单纯的依赖现有的motif...
Non-coding sequences, once thought to be transcriptionally inert, have been shown to be actively transcribed into a large variety ofnon-coding RNAs. They are now the object of intensive research due to their ability to participate in the regulation of nuclear structure and gene expression (Bonas...
coding noncoding 这两大类的分析方法截然不同,coding主要直接影响了mRNA和蛋白;而noncoding,主要是影响调控。 coding编码区如何分析? 通常有很多pipeline来预测WGS等得到的SNP的功能,如annovar等数据库。 protein binding domain 综述: Mapping genetic variations to three-dimensional protein structures to enhance varia...
A variety of approaches have been developed for detecting conserved noncoding sequences (CNSs) according to this principle (Duret and Bucher, 1997; Boffelli et al., 2003; Margulies et al., 2007). While such efforts have uncovered large numbers of CNSs, only some have been shown to contain ...
(CNCI), by profiling adjoining nucleotide triplets to effectively distinguish protein-coding and non-coding sequences independent of known annotations. CNCI is effective for classifying incomplete transcripts and sense-antisense pairs. The implementation of CNCI offered highly accurate classification of ...
Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell fitness via function-altering somatic “driver” mutations. To search for such drive