The non-canonical NF-κB pathway is tightly controlled by ubiquitin-dependent degradation of NIK mediated by an E3 ubiquitin ligase complex composed of cIAP family members, TNFR-associated factor 2 (TRAF2) and TRAF3; activation of non-canonical NF-κB involves signal-induced disruption of the cIA...
Anderson Cancer Center, The University of Texas Graduate School of Biomedical Sciences at Houston, 7455 Fannin Street, Box 902, Houston, TX 77030, USA The non-canonical NF-κB pathway is an important arm of NF-κB signaling that predominantly targets activation of the p52/RelB NF-κB complex...
non-canonical NF-kB signaling pathway. Cell Res. 21, 71-85. Trosky, J.E., Li, Y., Mukherjee, S., Keitany, G., Ball, H., and Orth, K. (2007). VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases. J. Biol. Chem. 282, 34299-34305.Sun, S. C. (...
The non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is an important component of NF-κB transcription complex. Activation of this pathway mediates the development and function of host immune system involved in inflammation and viral infection. ...
Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis. The former is dependent on the I...
Comparing Ly6Chi monocytes isolated from infarcted myocardium and bone marrow showed increased numbers of canonical WNT inhibitors (i.e., members of the β‐catenin destruction complex), whereas canonical WNT signaling mediators mostly decreased. By contrast, non‐canonical WNT/PCP pathway mediators and...
Conversely, the non-canonical NF-κB pathway exerts an opposing effect on type I IFN expression induced by the cGAS-STING signaling pathway because activated non-canonical NF-κB inhibits the recruitment of transcription factor RelA to the IFNB promoter, reducing type I IFN expression 18 . This...
Discussion TWEAK had previously been shown to have a proinflammatory effect dependent on canonical NFκB activation in podocytes, leading to the synthesis of the MCP-1 chemokine8,31. We now show that TWEAK also activates the non-canonical NFκB pathway in podocytes, promoting the ...
BCR-signalling activates the non-canonical NF-κB pathway and enhances the TLR-dependent canonical NF-κB pathway, thereby inducing activation-induced cytidine deaminase (AID), which is critical for class switch DNA recombination. Escherichia coli lipopolysaccharide (LPS) triggers dual TLR4/BCR-...
LINE1以非经典转录本变体形式剪切来调控T细胞静止和耗竭状态《Nature Genetics》意大利米兰大学,IF: 41.307,中科院一区 Cite:Marasca, F., Sinha, S., Vadalà, R. et al.LINE1 are spliced in non-canonical t…