Given the limited data on the prevalence of AGA by demographics, we evaluated prevalence of AGA by age at diagnosis (dx), sex, and race.Methods:A descriptive study used the US nationwide de-identified Flatiron Health-Foundation Medicine NSCLC clinico-genomic database. Eligible patients were ...
Immunotherapy, particularly immune checkpoint inhibitors, has become a cornerstone of treatment for AGA-negative NSCLC, either as monotherapy or in combination with chemotherapy, and is increasingly being utilized in the perioperative setting. Furthermore, emerging therapies such as bispecific antibodies, ...
non‑small cell lung cancer progression by sponging miR‑590‑5p to regulate THBS2 Liang Wang* , Lantao Zhao and Yonghong Wang Abstract Background: The incidence and death rate of non-small cell lung cancer (NSCLC) in China ranks the first among the malignant ...
Lung cancer is the most commonly diagnosed cancer as well as the leading cause of cancer-related deaths [1]. Non-small-cell lung cancer (NSCLC) accounts for approximately 83 % of all lung cancers, and nearly 80 % of NSCLC patients are diagnosed with advanced or distant stages [2]. So f...
We found that EGFRapt-3WJ-siKRASG12C nanoparticles potently depleted cellular KRASG12C expression, resulting in attenuation of downstream MAPK pathway signaling, cell proliferation, migration/invasion ability, and sensitized NSCLC cells to chemoradiotherapy. In vivo, these nanoparticles induced tumor ...
We retrospectively reviewed the charts of patients who had a pathological diagnosis of NSCLC at Aga Khan University Hospital, Nairobi (AKUHN) between January 2012 and December 2022. Data was analyzed for socio-demographic characteristics, smoking status, clinical stage, histological sub-type and ...
Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib. Mol Cancer Ther. 2009;8(2):292–302. CAS PubMed Google Scholar Georgakis GV, Li Y, Humphreys R, Andreeff M, O’Brien S, Younes M, ...
Interestingly, WISP3 effectively activated Wnt signaling pathway, and knockdown of WISP3 effectively blocked the influence of fibronectin on the migration, invasion and vascular structure formation potential of NSCLC cells. Our data also manifested that fibronectin elevated the transcription of WISP3 gene...
Metastasis is a significant factor that affects the survival of patients with non-small cell lung cancer (NSCLC). Nevertheless, the molecular regulatory mechanism underlying the metastasis is currently not fully understood. This study aims to identify th
Consistent with its molecular activity, re-expression of USP10 suppressed NSCLC cell proliferation and migration, whereas knockout of USP10 promoted NSCLC cell proliferation and migration. In conclusion, the present study demonstrates that USP10 coordinates TRIM25 to modulate PTEN activity. Specifically,...