Structure and Function of Myelinated Axons S.A.Buffington,M.N.Rasband, inPatterning and Cell Type Specification in the Developing CNS and PNS, 2013 35.9Conclusions and Outlook Nodes of Ranvier are absolutely essential for rapid, faithful, and efficient AP conduction in thenervous system. Althoug...
Schematic diagram showing the different domains of a myelinated neuron. The axonal region around the node of Ranvier is expanded to show the different axonal domains: the node of Ranvier where voltage-gated Na+channels are expressed, the paranode where the myelin is attached to the axon, and ...
1c, d). Taken together, these results suggest that chronic psychosocial stress alters the expression levels of genes involved in node of Ranvier structure and function in the mPFC of B6 and D2 susceptible mice. Fig. 1: Differential expression of nodes of Ranvier genes after chronic social ...
Node of Ranvier formation requires extrinsic interactions supplied by myelinating glia [2, 15••]. Development of PNS nodes as well as myelin is better understood than in the CNS (Figure 3a), because the system is much more tractable and in vitro models such as myelinating DRG neuron co...
Syndecan-3 (SDC3) and Syndecan-4 (SDC4) are distributed throughout the nervous system (NS) and are favourable factors in motor neuron development. They are also essential for regulation of neurite outgrowth in the CNS. However, their roles in the reconstruction of the nodes of Ranvier after...
8. Fluctuations in the firing threshold of neurones are expected from the stochastic gating of sodium channels. A prediction of the size of these fluctuations based on the measured properties of the channels gives a value of about 1% for the relative spread, which agrees with experimental values...
of Ranvier (NOR) on axons are key elements of the brain’s network signaling machinery, changes in their integrity have not been studied in context with DAI. Here, we utilized a clinically relevant swine model of concussion that induces evolving axonal pathology, demonstrated by accumulation of ...