provides a brief overview of TFH cells with special emphasis on function and phenotype and a more detailed discussion of clinical, morphologic, immunophenotypic and genotypic characteristics of AITL, follicular T-cell lymphoma and nodal PTCL with TFH phenotype which constitute nodal TCLs of TFH origin...
Discrepancies between these studies could be because helper T-cell markers (TFH markers), such as PD1, whereas of inherent differences in the techniques used. PTCL-NOS expresses the highest levels of JUNB, BLIMP1, RelB, BLIMP1 and JUNB are two NF-kB genes that are important in p52 and ...
Large cell PTCL-TFH patients had significantly lower populations of clear neoplastic cells and fewer reactions of eosinophils and plasma cells than those of AITL (Fig. 1a, b; both p < 0.01). Large cell PTCL-TFH expressed more than two TFH markers; among them PD-1 was positive in 12...
Patients with recurrent peripheral T-cell lymphoma (PTCL) after allogeneic hematopoietic cell transplantation (HCT) have dismal outcomes. Nodal PTCL with the T follicular helper phenotype (PTCL-TFH) is uniquely sensitive to histone deacetylase inhibitors compared to non-TFH phenotypes. We report the ...
PTCL may have a perifollicular growth pattern mimicking NMZL. We and others have noted an atypical distribution of T-follicular helper (TFH) cells in some cases of NMZL. This study was prompted by the diagnosis of NMZL in several cases in which a marked increase of TFH cells, as determined...
Unsupervised clustering correlated with the pathological classification and with CD30 expression in PTCL-u. The molecular profile of AITLs was characterized by a strong microenvironment imprint (overexpression of B-cell- and follicular dendritic cell-related genes, chemokines, and genes related to ...
Aims To evaluate the role of the follicular helper T (TFH) cell markers, CD10, BCL6, programmed death-1 (PD-1) and CXCL13, in the differential diagnosis of nodal peripheral T cell lymphomas (PTCLs) and to determine whether PTCL subtypes other than angioimmunoblastic T cell lymphoma (...
Herein, we summarize key features of F-PTCL and briefly review the evolving relationship to other nodal T-cell lymphomas/lymphoproliferative disorders of TFH-derivation.doi:10.1007/s12308-021-00460-wRamos, JoseanRush UnivWard, NicholasSpringer Berlin Heidelbergjournal of hematopathology...