PTCL with TFH PhenotypeRefractoryImmunomodulationPatients with recurrent peripheral T-cell lymphoma (PTCL) after allogeneic hematopoietic cell transplantation (HCT) have dismal outcomes. Nodal PTCL with the T follicular helper phenotype (PTCL-TFH) is uniquely sensitive to histone deacetylase inhibitors ...
In peripheral T-cell lymphomas (PTCLs), angioimmunoblastic T-cell lymphoma (AITL) and follicular T-cell lymphoma (F-TCL) are derived from TFH cells and defined by expression of two or more TFH markers (TFH+) [2, 3]. Furthermore, less than half of patients with PTCL-not otherwise ...
Discrepancies between these studies could be because helper T-cell markers (TFH markers), such as PD1, whereas of inherent differences in the techniques used. PTCL-NOS expresses the highest levels of JUNB, BLIMP1, RelB, BLIMP1 and JUNB are two NF-kB genes that are important in p52 and ...
provides a brief overview of TFH cells with special emphasis on function and phenotype and a more detailed discussion of clinical, morphologic, immunophenotypic and genotypic characteristics of AITL, follicular T-cell lymphoma and nodal PTCL with TFH phenotype which constitute nodal TCLs of TFH origin...
The 2016 revised edition of the WHO-classification of Tumors of the Haematopoietic and Lymphoid Tissues [1] has modified the body of nodal PTCLs, by introducing the new category of angioimmunoblastic (AITL) and other nodal T-cell lymphomas of follicular helper T-cell (TFH) phenotype. With ...