NOD-like Receptor Signaling PathwayOverview Diagram Introduction The innate immune system is the first line of defense against microbial invasion, relying on pattern recognition receptors to recognize external pathogenic microorganisms and then remove them. Toll-like receptors (TLRs) and Nod-like receptors...
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling ...
NOD-like Receptor Signaling Pathways Oncostatin M Signaling Pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways T Cell Co-Signaling Pathway: Ligand-Receptor Interactions TGF-beta Signaling Pathways Th1 Differentiation Pathway ...
This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway. Keywords: NOD-like receptor; gastrointestinal inflammatory ...
NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish - ScienceDirect 来自 Elsevier 喜欢 0 阅读量: 81 作者:Yongzhan Mai a,Songyao Peng a,Haiyan Li a,Yuan Gao a,Zini Lai a b c ...
Ubiquitin specific protease 21 upregulation in breast cancer promotes cell tumorigenic capability and is associated with the NOD-like receptor signaling pathway... Liang,Peng,Hu,... - 《Oncology Letters》 被引量: 0发表: 2016年 Ubiquitin specific protease 21 upregulation in breast cancer promotes ...
NOD-like receptor signaling pathway Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recogniti...
Furthermore, the nucleotide-binding, oligomerization domain (NOD)-like receptor signaling pathway was significantly enriched and most of the genes in this pathway exhibited enhanced expression after BaP exposure. These results partially explained the mechanisms underlying the toxic effects of BaP on ...
Overall, transcriptional alterations may contribute to the physiological responses in zebrafish under BaP exposure. Extracellular BaP could trigger the up-regulation of gene expression NOD-like receptor signaling pathway. An enhanced expression of these genes leads to an increase in cytokines IL-1β and...
The comparative transcriptome analysis revealed that the diseased bullfrog brain was characterized by the immune activation and inflammatory response, which were mediated by the "NOD-like receptor signaling pathway" and the "Toll-like receptor signaling pathway". We also performed qRT-...