The hairless mice, and has multiple immune defects, including B cells and T cell defects, and impaired macrophage and complement function. 所述小鼠还在免疫系统的自然杀伤细胞和树突细胞中具有进一步的缺陷. The mouse is also natural killer cells and dendritic cells of the immune system has the ...
Immunocompromised mice enable human tumors to be implanted subcutaneously or orthotopically (into a target organ) without danger of the mouse rejecting the foreign tissue. For this purpose, athymicnude mice or NOD/SCID mice are used. However, human response to tumor invasion includes an immune comp...
经照射后的NOD/SCID小鼠通过移植人脐血CD34细胞成功地建立了hu-SRC—NOD/SCID模型,并有效地重建了 小鼠细胞免疫系统。 [关键词] NOD/SCID小鼠;CD34细胞;移植;细胞免疫重建 【中图分类号] 11392.4;R331.2;R733 【文献标志码] A Post—transplantcellimmunereconstitutioninhumanizedNOD/SCIDmice ...
促进细胞的凋亡,并且在体外实验中用SK-BR-3乳腺癌细胞系和对雌激素敏感的MCF-7乳腺癌细胞系构建了NOD1敲除和NOD1过表达的细胞,发现NOD1在这2个细胞系中均能调控细胞凋亡通路,随后他们通过scid小鼠移植瘤模型证实NOD1对雌激素敏感的肿瘤...
NSG mouse strain is an immunodeficient mouse that knocks out the interleukin 2 receptor gamma chain (IL2Rγ) gene on the basis of NOD/SCID[77]. This mice strain lacks mature T and B lymphocytes and completely loses NK cell activity[78]. Compared with NOD/SCID mice, the transplantation ...
应用领域:immune system *使用本品系发表的文献需注明: MHC Class II(I-A/I-E)-KO(Nod-Scid) mice (Cat. NO. NM-KO-18057) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 M-NSG 品系名:NOD.Cg-PrkdcscidIl2rgem1Smoc ...
Da Silva Correia等[29]首次证实NOD1与肿 瘤有关,发现NOD1可作为TNF通路的一个增 敏剂,促进细胞的凋亡,并且在体外实验中用 SK-BR-3乳腺癌细胞系和对雌激素敏感的MCF-7 乳腺癌细胞系构建了NOD1敲除和NOD1过表 达的细胞,发现NOD1在这2个细胞系中均能 调控细胞凋亡通路,随后他们通过scid小鼠移 植瘤模型证实...
the therapeutic effect and mechanism of human interleukin 12 gene on the treatment of hepatocellular carcinoma in the murine models.Method: 1.To establish the HCC-hu-PBL-NOD/SCID model, NOD/SCID mice were injected with HepG2 cells subcutaneously, and then with human PBL; 2.The mice were ...
NOD-scid IL2R γnull mice were engrafted with hPBMC derived from patients suffering from AD and from healthy volunteers and treated with IL-4 or the IL-4 antagonist/inhibitor Pitrakinra. We chose IL-4 and its inhibitor Pitrakinra as a model system as the effects of both have been ...
The latest improvement in the development of immune- deficient mouse strains are NOD/scid mice. By crossing the scid mutation onto the NOD background, a mouse strain with a complex immune-deficiency involving B and T lymphocytes, NK cells, macrophages, and the complement system was cre- ated ...