其通过模式识别受体(pattern recognition receptors,PRR)[1]来非特异地识别各种致病物质,PRR主要有以下两类受体:一类是位于细胞膜表面或内体膜上的Toll样受体(Toll-like receptor,TLR),另一类是位于细胞质内的核苷酸结合寡聚化结构域(nucl...
TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions Toll-Like Receptor Signaling Pathways Type I Interferon Signaling Pathways Type II Interferon Signaling Pathways Type III Interferon Signaling Pathways VEGF - VEGF R2 Signaling Pathways ...
factors through a variety of signaling pathways. This review presents the constitution of NOD-like receptor, NOD-mediated signaling pathways and the relationship between NOD-like receptor and tumors.［Key words ］ Nucleotide-binding oligomerization domain-like receptor; Signaling pathway; Tumor ...
【关键词】 NOD 样受体; 急性腹腔感染; 肠屏障; 信号通路 Effect mechanism of NOD like receptor signaling pathway on intestinal mucosal barrier of rat during early phase of acute intra -abdominal infection XIAO Yuan -ting*, LI Guo -xun,WANG Xi -mo. *Department of General Surgery, Tianjin ...
Electroacupuncture inhibiting LPS-induced chronic neuroinflammation by regulating the cortical NF-κB/NOD-like receptor protein 3 signaling pathway 在线阅读 免费下载 引用 收藏 分享 摘要 目的观察电针对脂多糖诱导的慢性神经炎症小鼠的NF-κB/NOD样受体蛋白3(NLRP3)信号通路及其小胶质细胞形态的影响,探究电针对...
[Abstract] NOD-like receptor is a new type of intracytoplasmic inherent immune pattern recognition receptors,which Play an important role in immune response.Once activated,these molecules trigger intracellular signaling pathways that lead to the activation of transcriptional responses culminating in the ...
其通过模式识别受体(pattern recognition receptors,PRR) [1] 来非特异地识别各种致病物质,PRR主要有以下两类受体:一类是位于细胞膜表面或内体膜上的Toll样受体(Toll-like receptor,TLR),另一类是位于细胞质内的核苷酸结合寡聚化结构域(nucleotide- binding oligomerization domain,NOD)样受体及视黄酸诱导基因(retinoic...
细胞焦亡过程涉及多种炎症小体信号通路的激活,其中对NOD样受体家族Pyrin域蛋白(NOD-like receptors family Pyrin domain containing,NLRP)3炎症小体的研究较深入。目前,研究结果证实,NLRP3炎症小体诱导的细胞焦亡在骨髓增生异常综合征(myelodysplastic syndromes,MDS)发病中发挥重要作用 [ 1 ]。但是细胞焦亡是否参与除MDS...
先天免疫系统由几种模式识别受体组成,包括 Toll 样受体(Toll-like receptors,TLRs),NOD 样受体 (NOD-like receptors,NLRs)和 RIG-1 样受体(RIG-1 like receptors,RLRs).TLRs 在细胞表面和核内体识 别细菌,而 NLRs 和 RLRs 在细胞溶质中检测细菌成 分.哺乳动物 TLRs 可以感受细胞表面及核体中由 细菌引起和...
[Key words] Nucleotide-binding oligomerization domain-like receptor; Signaling pathway; Tumor 先天性免疫应答是机体抗感染免疫的第 一道防线,相对于适应性免疫应答来说具有 出现早,应答发生速度快等特点.其主要识 别病原体相关分子模式(pathogen-associated molecular patterns,PAMPs)和损伤相关的分 子模式(damage-...