其通过模式识别受体(pattern recognition receptors,PRR)[1]来非特异地识别各种致病物质,PRR主要有以下两类受体:一类是位于细胞膜表面或内体膜上的Toll样受体(Toll-like receptor,TLR),另一类是位于细胞质内的核苷酸结合寡聚化结构域(nucl...
factors through a variety of signaling pathways. This review presents the constitution of NOD-like receptor, NOD-mediated signaling pathways and the relationship between NOD-like receptor and tumors.［Key words ］ Nucleotide-binding oligomerization domain-like receptor; Signaling pathway; Tumor ...
[Key words] Nucleotide-binding oligomerization domain-like receptor; Signaling pathway; Tumor 先天性免疫应答是机体抗感染免疫的第 一道防线,相对于适应性免疫应答来说具有 出现早,应答发生速度快等特点.其主要识 别病原体相关分子模式(pathogen-associated molecular patterns,PAMPs)和损伤相关的分 子模式(damage-...
View NOD-like Receptor Signaling Pathways Image Related Information NLRP10 Is Required for Dendritic Cell-mediated Initiation of the Adaptive Immune Response NOD-like Receptors and the Inflammasome Obesity-Induced Activation of the Nlrp3 Inflammasome Promotes Insulin Resistance...
[Abstract] NOD-like receptor is a new type of intracytoplasmic inherent immune pattern recognition receptors,which Play an important role in immune response.Once activated,these molecules trigger intracellular signaling pathways that lead to the activation of transcriptional responses culminating in the ...
NOD 样受体通路在急性腹腔感染早 期对大鼠肠屏障的作用机制初探 [J]. 中华危重病急救医学, 2013, 25 (9): 527蛳532. DOI:10.3760/cma.j.issn.2095蛳4352.2013. 09.005. Xiao YT, Li GX, Wang XM. Effect mechanism of NOD like receptor signaling pathway on intestinal mucosal barrier of rat during ...
先天免疫系统由几种模式识别受体组成,包括 Toll 样受体(Toll-like receptors,TLRs),NOD 样受体 (NOD-like receptors,NLRs)和 RIG-1 样受体(RIG-1 like receptors,RLRs).TLRs 在细胞表面和核内体识 别细菌,而 NLRs 和 RLRs 在细胞溶质中检测细菌成 分.哺乳动物 TLRs 可以感受细胞表面及核体中由 细菌引起和...
细胞焦亡过程涉及多种炎症小体信号通路的激活,其中对NOD样受体家族Pyrin域蛋白(NOD-like receptors family Pyrin domain containing,NLRP)3炎症小体的研究较深入。目前,研究结果证实,NLRP3炎症小体诱导的细胞焦亡在骨髓增生异常综合征(myelodysplastic syndromes,MDS)发病中发挥重要作用[ 1 ]。但是细胞焦亡是否参与除MDS...
(NOD-like receptors ,NLRs )和 RIG-1 样受体 (RIG-1 与获得性免疫系统相 比,先天免疫不需要基 因重组 , like receptors ,RLRs )。TLRs 在细胞表面和核 内体识 它 的多样性依赖于若干先天免疫基 因,它们 的接合 别细菌 ,而 NLRs 和 RLRs 在细胞溶质 中检测细菌成 变异型编码在宿主基 因组 中[1] ...
Effect of Guizhi Tang drug serum on the expression of Toll-like receptors and downstream signaling components in RAW 264.7 cells; 桂枝汤含药血清对小鼠巨噬细胞Toll样受体3、4型及其下游信号转导通路元件的影响 更多例句>> 4) toll like receptor Toll样受体 1. Toll like receptor (TLR) belong to...