其通过模式识别受体(pattern recognition receptors,PRR)[1]来非特异地识别各种致病物质,PRR主要有以下两类受体:一类是位于细胞膜表面或内体膜上的Toll样受体(Toll-like receptor,TLR),另一类是位于细胞质内的核苷酸结合寡聚化结构域(nucl...
signaling pathways process.:To study the expression of cellular pattern recognition receptors nucleotide-binding oligomerization domain containing in the corneal cell and the role of activate the innate immune of corneal cell, to explore the mutual relations with the Toll-like receptor TLR4 in this ...
慢性炎症可导致HS/PC功能障碍和免疫细胞分化异常,血液系统恶性肿瘤通常存在炎症细胞因子水平增高,而NLRP3炎症小体在其中发挥重要作用。细胞焦亡是否存在于除MDS外的血液系统恶性肿瘤,如白血病发病中目前尚存争议,但是细胞焦亡过程中的NLRP3炎症小体与白血病等血液系统恶性肿瘤关系密切。NLRP3炎症小体究竟如何参与白血病的...
Mitchell HM: The NOD-Like Receptor Signalling Pathway in Helicobacter pylori Infection and Related Gastric Cancer: A Case-control Study and Gene Expression ... N Castaño-Rodríguez,NO Kaakoush,AL Pardo,... - 《Human Immunology》 被引量: 51发表: 2014年 The NOD-like receptor signalling pathw...
先天免疫系统由几种模式识别受体组成,包括 Toll 样受体(Toll-like receptors,TLRs),NOD 样受体 (NOD-like receptors,NLRs)和 RIG-1 样受体(RIG-1 like receptors,RLRs).TLRs 在细胞表面和核内体识 别细菌,而 NLRs 和 RLRs 在细胞溶质中检测细菌成 分.哺乳动物 TLRs 可以感受细胞表面及核体中由 细菌引起和...
[Abstract] NOD-like receptor is a new type of intracytoplasmic inherent immune pattern recognition receptors,which Play an important role in immune response.Once activated,these molecules trigger intracellular signaling pathways that lead to the activation of transcriptional responses culminating in the ...
An overview of the NOD-like receptor signaling pathway, introduction, the regulation of pathway and clinical significance.
Toll样受体(toll-like receptors,TLRs)在天然免疫系统中是模式识别受体(pattern recognition receptor,PRR)里保守的一大家族,作为一类特定受体在人体免疫系统中扮演着重要作用,而TLR4是最早发现的TLRs家族成员,在参与天然免疫中发挥重要作用...
Get Print Copy of this Pathway View NOD-like Receptor Signaling Pathways Image Related Information NLRP10 Is Required for Dendritic Cell-mediated Initiation of the Adaptive Immune Response NOD-like Receptors and the Inflammasome Obesity-Induced Activation of the Nlrp3 Inflammasome Promotes Insulin Resistan...