low back pain, intervertebral disc, posterior longitudinal ligament, acetylcholinesterase, calcitonin gene-related peptide, tyrosine hydroxylaseDespite the various classical works, the mechanism of chronic low back pain has not been fully understood. Recent improvement of neuroanatomical techniques has enabled...
These results indicate that the secretion of NGF from cancer cells in low-glucose environments depends on the JNK-c-Jun pathway. We conducted in vivo experiments and found that both NGF and p-c-Jun protein levels were increased in the cancer cells of 2-DG-treated Cal27 tongue xenografts (...
This review emphasizes that proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-17 are also mediators of pain by directly acting on the nociceptive system. Proportions of nociceptive sensory neurons express receptors for these cytokines, and the...
This review emphasizes that proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-17 are also mediators of pain by directly acting on the nociceptive system. Proportions of nociceptive sensory neurons express receptors for these cytokines, and the...
Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain 2015, Nature Communications Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation 2014, PLoS ONE View all citing articles on Scopus...
This demonstrates the efficacy of the Nav1.8-DTA system and combined with the original reference characterizing the pain phenotype of these mice illustrates that a subset of peptidergic TRPV1+ nerve fibres is spared. d, Representative confocal micrograph of whole-mount ear skin of vehicle- and ...
This is relevant to pain management in a large array of human diseases where inflammation is a major contributor of hyperalgesia. Based on the findings reported here, we propose a model for TRPV1 regulation of inflammatory thermal hyperalgesia through a pathway that involves SUMOylation of the ...
low back pain, intervertebral disc, posterior longitudinal ligament, acetylcholinesterase, calcitonin gene-related peptide, tyrosine hydroxylaseDespite the various classical works, the mechanism of chronic low back pain has not been fully understood. Recent improvement of neuroanatomical techniques has enabled...
Specific nociceptive fibers projecting from spinal cord neurons to the brain: a possible pathway for pain Author links open overlay panelB.PomeranzShow more Share Cite https://doi.org/10.1016/0006-8993(73)90749-XGet rights and contentPrevious article in issue Next article in issue...
The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature, 389 (1997), pp. 816-824 View in ScopusGoogle Scholar Caterina et al. 2000 M.J. Caterina, A. Leffler, A.B. Malmberg, W.J. Martin, J. Trafton, K.R. Petersen-Zeitz, M. Koltzenburg, A.I. Basbaum,...