Presents an article on pharmacologic management of pain. Adaptive and maladaptive categories of pain; Nociceptive pain system as a key early warning device that announces the presence of a potentially damaging stimulus; Mechanisms of pain such as nociception, peripheral sensitization, and phenotypic ...
These patient are said to have sympathetically maintained pain(SMP). In normal tissue, activity in postganglionic sympathetic efferents does not produce pain, nor is it capable of activating nociceptive sensory neurones. It can, however, induce modest firing in some mechanoreceptors. SMP is often...
Define neuromechanism. neuromechanism synonyms, neuromechanism pronunciation, neuromechanism translation, English dictionary definition of neuromechanism. the structure and arrangement of the nervous system in relation to function. See also: Medical Spec
Mechanism of pain generation for endometriosis-associated pelvic pain Endometriosis-associated pelvic pain appears due to persistent nociceptive stimulation, but the precise mechanisms remain poorly understood.A search was co... H Kobayashi,Y Yamada,S Morioka,... - 《Archives of Gynecology & Obstetrics...
Presents an article on pharmacologic management of pain. Adaptive and maladaptive categories of pain; Nociceptive pain system as a key early warning device that announces the presence of a potentially damaging stimulus; Mechanisms of pain such as nociception,...
闸门理论,称那些激活但不传递疼痛信号的神经为非感受伤害性纤维(nonnociceptive fibers),它们可以干涉源自疼痛纤维(pain fibers)的信号,从而可以抑制疼痛。传入疼痛感受神经(见图 1,高中生物中有讲述:胞体在脑、脊神经节内,神经末梢在皮肤和肌肉等部位形成感受器)将信号传入中枢神经,包含至少两种神经纤维: ...
Tominaga found that nociceptive responses are increased by anoctamin 1 activated by TRPV1 which binds to anoctamin 1 in the analyses using sensory neurons andspinal cordof mice. In addition, they proved that chemical blockade of anoctamin 1 is effective for relief of pain induced by TRPV1 ...
In the development of bone cancer pain,different pathological changes,such as simultaneous inflammation,nerve injury and other tissue damage can increase nociceptive stimulus transmission,and evoke severe pain.Here we summarized the progress in the study of peripheral mechanisms underlying bone cancer pain...
Giordano et al[116] showed that 5-HT3 contributes to chemical but not thermal and mechanical nociceptive pain. 5-HT2A potentiates the effects of other inflammatory mediators[117]. In the study by Tokunaga et al[118], only the 5-HT2A agonist but not 5-HT1A and 5-HT3A agonists mimicked...
CAMP-dependent protein kinase inhibitor alpha (PKIA) has been reported involved in the diminished inflam- mation and nociceptive pain108. For inhibiting the contraction of uterine smooth muscle, molecules luteolin was found to target monoamine oxidase A (MAOA), which affects the secretion of the ...