Activation of pain modulation systems usually results in less activity in the pain transmission pathway following a noxious stimulus. Examples of activation of this process include stress-induced analgesia. However, in some circumstances modulation can also result in an enhancement of pain signaling. ...
8), which integrates the inter-modality crosstalk between the nociceptive pathway and Aβ-LTMRs and the inter-somatotopy crosstalk among Aβ-LTMRs at different spinal segments, to explain the complicated phenotypes of Aβ-LTMRs in mechanical hyperalgesia. Our model suggests that the global ...
Willis WD, Jr., Westlund KN (2001) The role of the dorsal column pathway in visceral nociception. Curr Pain Headache Rep 5:20–26W. D. Willis Jr. and K. N. Westlund, "The role of the dorsal column pathway in visceral nociception," Current Pain and Headache Reports, vol. 5, no....
Prostaglandins (PGs) formed via the cyclooxygenase (COX) pathway mediate hyperalgesia in sensory nerve endings. To investigate the role of the COX isoforms in pain transmission we recently studied nociception in COX-isozyme-deficient mice using models of "sharp" rapidly transmitted pain (hot-plate) ...
Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: involvement of the NO/cGMP/PKG/KATP signaling pathway. Through activation of the A1 adenosine receptors (A1Rs) at both the central and peripheral level, adenosine produces antinociception in a wide range of tes.....
However, these particular compounds cannot be used to address whether non-electrophilic activation of TRPA1 also produces spinal antinociception, because they also interact with other targets in the nociceptive pathway. Therefore, on the basis of the structure of ∆9-tetrahydrocannabinol, we ...
Stimulation of peripheral Kappa opioid receptors inhibits inflammatory hyperalgesia via activation of the PI3Kγ/AKT/nNOS/NO signaling pathway Background In addition to their central effects, opioids cause peripheral analgesia. There is evidence showing that peripheral activation of kappa opioid r... TM...
In addition to stimulating release ofendogenous opioids, recent evidence at the cellular level suggests that NSAIDs may also augment the signaling pathway used by opiates, potentiating the actions of exogenous opioids (Figure 3). Coapplication of NSAIDs potentiates the inhibition ofGABArelease by theM...
d, Schematic indicating the various stimuli which activate STING and its downstream pathway. See Supplementary Information for complete sample sizes, sex, and statistical information. Source data Extended Data Fig. 2 Antinociceptive effects of STING agonists in naive mice and in mouse models of ...
BF neurons showed a higher preference to tactile input than Dys neurons (Fig.2c). Because L5 neurons are suggested to modulate nociceptive inputs through the corticofugal pathway14,15, BF L5 neurons might relate to touch-induced pain relief under normal conditions51, while Dys L5 neurons might...