Importantly, the chemical structure of the linkage of GAC to peptidoglycan has not been addressed. Fig. 1: Analysis of GAC released from the GAS cell wall by chemical treatments. a Molecular model illustrating GAC covalently attached to peptidoglycan via a phosphodiester bond. GAC contains a →...
61. An immunoconjugate having the formula (A)-(L)-(C), wherein: (A) is a biparatopic antibody or antigen binding fragment of comprising: a first FRα-binding domain that comprises a first variable heavy chain (VH) comprising VH CDR1-3 comprising the amino acid sequences of (a) SEQ...
In spite of these differences, the two drugs have their aglycone inserted the same way in DNA. The intercalation of nogalamycin into DNA presents a mechanistic problem, since the dumbbell shape of the intercalator with its bulky sugar residues presumably requires substantial deformation of the DNA...