apoptosisOur previous studies have indicated that non-muscle myosin heavy chain IIA (NMMHC IIA) is involved in H O -induced neuronal apoptosis, which is associated with the positive feedback loop of caspase-3/ROCK1/MLC pathway. However, the neuroprotective effect of NMMHC IIA inhibition with ...
NMMHC IIA-induced autophagy is through its interactions with F-actin and ATG9A in response to OGD/R. The NMMHC IIA–actin interaction contributes to ATG9A trafficking and autophagosome formation. Inhibition of the NMMHC IIA–actin interaction using blebbistatin and the ...
Purpose:To evaluate whether YQFM has neuroprotective effects on cerebral ischemia/reperfusion-induced injury by inhibiting NMMHC IIA-actin-ATG9A interaction for autophagosome formation. Methods:The neuroprotective effects of YQFM were investigated in vivo in mice with middle cerebral artery occlusion/...
Furthermore, NMMHC IIA-induced autophagy is through its interactions with F-actin and ATG9A in response to OGD/R. The NMMHC IIA鈥揳ctin interaction contributes to ATG9A trafficking and autophagosome formation. Inhibition of the NMMHC IIA鈥揳ctin interaction using blebbistatin and the F-actin ...
Pecoraro C, Koivisto PA, Heller PG, Iolascon A, Alvisi P, Schwabe D, De Candia E, Rocca B, Russo U, Ramenghi U, Noris P, Seri M, Balduini CL, Savoia A (2008) Position of nonmuscle myosin heavy chain IIA (NMMHC-IIA) mutations predicts the natural history of MYH9-related disease...
Furthermore, siRNA knockdown of NMMHC IIA, but not IIB or IIC, inhibited TF expression, activated Akt/GSK3 and suppressed NF-κB signalling pathways, whereas the overexpression of NMMHC IIA increased TF expression. The binding of NMMHC IIA and TNF receptor 2 mediated signal internalisation in ...
Immunohistochemistry for NMMHC-IIA in the liver biopsy from one patient with MYH9-RD.Alessandro, PecciGinevra, BiinoTiziana, FierroValeria, BozziAnnamaria, MezzasomaPatrizia, NorisUgo, RamenghiGiuseppe, LoffredoFabrizio, FabrisStefania, Momi
Here we reported that ruscogenin (RUS), an effective steroidal sapogenin of Radix Ophiopogon japonicus, attenuated lipopolysaccharides (LPS)-induced pulmonary endothelial barrier disruption through mediating non-muscle myosin heavy chain IIA (NMMHC IIA)Toll-like receptor 4 (TLR4) interactions. By...
Moreover, we identified that RUS directly targeted NMMHC IIA on its N-terminal and head domain by serial affinity chromatography, molecular docking, biolayer interferometry, and microscale thermophoresis analyses. Downregulation of endothelial NMMHC IIA expression in vivo and in vitro abolished the ...
Author correction to'Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TL R4 signaling'[Acta Pharmaceutica Sinica B 12(2022)1198-1212] correctionfigurepictureThe authors regret that there were some errors or inexact de-scriptions in ...