The invention belongs to the field of biotechnology, relates to a skeletal muscle specificity MYHC-IIa promoter and an application thereof, and particularly provides a specificity promoter of a skeletal muscle specificity expression gene 5' control region, and an application thereof in transgenic swine...
本发明属于生物技术领域,涉及一种骨骼肌特异性MYHC-IIa启动子及其应用,特别提供了一种骨骼肌特异性表达基因5′调控区特异性启动子及其在转基因猪中的应用,该启动子只在骨骼肌中具有启动特性,而在除骨骼肌外的多种细胞中均无启动活性,可见该基因启动子只在骨骼肌中特异性地启动下游基因的表达,因此能够满足目的基因...
Genetic analysis disclosed that MyHC IIA/X-AS stimulates cell cycle exit of skeletal satellite cells and their fusion into myotubes. Moreover, we observed that MyHC IIA/X-AS is more enriched in fast-twitch muscle and represses slow-type gene expression and thereby maintains the fast phenotype. ...