NMDA Receptor Antagonists as Antidepressant and Antidementia Drugs: Recent Developments and Future ProspectsantidementiaantidepressantcognitiondementiadepressionglutamatememorymoodN-Methyl-D-aspartate (NMDA) receptor (NR) antagonists have contributed to the major advances in research of excitatory synaptic ...
Systemic administration of noncompetitive NMDA receptor antagonists, such as MK-801, produces a period of intoxication followed by non- rapid eye movement (NREM) sleep with greatly elevated delta EEG activity. We have hypothesized that the delayed NREM delta EEG increase is a homeostatic response ...
The above results indicate that the anticataleptic activity of both these NMDA receptor antagonists is induced by an indirect activation of the dopamine system. The results provide further evidence that competitive NMDA receptor antagonists may be a new class of antiparkinsonian drugs.doi:10.1002/hup....
a–dChemical structures of uncharged forms of additional NMDAR channel blockers examined (left); examples of current traces during MCI protocols performed at pH 7.2 using GluN1/2A receptor-expressing tsA201 cells; overlays of IControland IMCI(IMCIin red); IMCI/IControlpoint-by-point ratios (rig...
The combinations of l -dopa and each of the NMDA receptor antagonists did not significantly improve stepping more than either drug alone. Moreover, none of the drugs completely eliminated the stepping deficits, and high doses began to impair stepping with the ipsilateral paw by inducing turning....
Rationale: There is evidence that drugs that improve or impair learning can facilitate or block ethanol tolerance, respectively. Since GABA[sub B] receptor... Zaleski,Marcos,Jose,... - 《Psychopharmacology》 被引量: 38发表: 2001年 Effects of SR141716 and WIN 55,212-2 on tolerance to ethanol...
Jakisch R, Kruchen A, Sauermann W, Hertting G, Feuerstein TJ (1994) The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonists. Eur J Pharmacol 264: 207–211JACKISCH, R. , KRUCHEN, A. , SAUERMANN, W. , HERTTING, G. & FEUERSTEIN, ...
The aim of this article is to provide a review of studies using N-methyl-d-aspartate (NMDA) receptor antagonists to assess the hippocampal long-term potent
Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs. Brain Res Brain Res Rev 2000; 31(2-3): 320- 9.Svensson TH. Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of ...
Additionally, hypoxic potentiation of receptor inhibition, as seen with NO-based compounds22, is a particularly desirable fea- ture in ischemia. Thus, hypoxia-regulated, allosterically-targeted NMDAR antagonists, although of low affinity, may hold promise for cerebrovascular and other neurodegenerative ...