1) NMDA receptor agonist NMDA受体激动剂例句>> 2) NMDA receptor antagonist NMDA受体拮抗剂 1. objective The effect was investigated to induce NSC proliferation and differentiation in the adult rat SGZ、SVZ and cortex by NMDA receptor antagonist administration following focal ischemic insults produced ...
右美沙酮: 一种NMDA receptor拮抗剂药物,由Relmada Therapeutics, Inc. (Relmada Therapeutics, Inc.)公司最早进行研发,目前全球最高研发状态为临床3期,作用机制: NMDA receptor拮抗剂(谷氨酸[NMDA]受体复合体拮抗剂),治疗领域: 其他疾病,神经系统疾病,内分泌与代谢疾病
Kathleen Clarence-SmithJean-Marie Georges ContrerasLaurence Nathalie DeyonCamille Georges WermuthUS
AUVELITY is a novel, oral, NMDA receptor antagonist with multimodal activity approved for the treatment of MDD in adults. AUVELITY is a proprietary extended-release oral tablet containing dextromethorphan HBr (45 mg) and bupropion HCl (105 mg). The dextromethorphan component of AUVELITY is an an...
This study investigated the excitotoxic properties of a novel series of NMDA analogues in which a methyl group was introduced to the 5-position of the pyrrolidine ring of L-trans-2,3-PDC, a previously identified NMDA receptor agonist. While all of these compounds induced NMDA-receptor-mediated...
Moreover, intra-vlPAG GLYX-13 microinjection produced a long-lasting antidepressant effect; however, this effect was prevented by the intra-vlPAG microinjection of tropomyosin-related kinase B (TrkB) receptor antagonist ANA-12, a selective mammalian target of rapamycin complex 1 (mTORC1) inhibitor...
Am J Psy- chiatry 119:61–67 Luciana M, Depue RA, Arbisi P, Leon A (1992): Facilitation of working memory in humans by a D2 dopamine receptor agonist. J Cog Neurosci 4(1):58–68 Malhotra AK, Pinals DA, Adler CM, Elman I, Clifton A, Pickar D, Breier A (1997): Ketamine-...
www.nature.com/scientificreports OPEN Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist received: 02 November 2014 induced conformational states ofaccepted: 08 May 2015 the channel vestibulePublished: 18 June 2015 Vojtech Vyklicky1, Barbora Krausova1, Jiri...
The etiology and pathogenesis of “anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis” and the role of autoantibodies (AB) in this condition are still obscure. While NMDAR1-AB exert NMDAR-antagonistic properties by receptor internalization, no firm
Intriguingly, treatment with D-serine (a co-agonist of NMDA receptor, 1g/kg intraperitoneally) reduced the anxiety-like behavior but not the mechanical ... Wang, Xue-Qin,Zhong, Xiao-Lin,Li, Zhi-Bin,... - 《Bmc Neuroscience》 被引量: 15发表: 2015年 Timing-dependent reduction in ethanol ...