Encephalitis in otherwise healthy individuals is generally thought to be of viral origin. If results of viral studies are negative and symptoms persist, whole body CT or PET imaging and serological investigation are used to identify paraneoplastic causes. Antibodies detected in the sera or CSF of ...
Subacute Sclerosing Panencephalitis: More Cases of This Fatal Disease Are Prevented by Measles Immunization than Was Previously Recognized The most severe sequela of measles virus infection is subacute sclerosing panencephalitis (SSPE), a fatal disease of the central nervous system that genera... WJ ...
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an anti-neuronal antibody-mediated inflammatory brain disease that causes severe psychiatric and neurological deficits in previously healthy patients. The aims of this study were to demonstrate the clinical characteristics of patients diagnosed with...
Second only to acute disseminated encephalomyelitis, anti-NMDAR encephalitis was a significant cause of autoimmune cases, constituting 6% of all patients. In addition, the State of California encephalitis registry found...
Relapsing anti-NMDAR encephalitis is defined as any new psychiatric or neurologic syndrome that cannot be explained by other causes and that improved after immunotherapy or, less frequently, spontaneously, different studies have described abnormalities in CSF, EEG, and MRI. These are not as frequent ...
G. et al. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J. Neurosci. 30, 5866–5875 (2010). CAS PubMed PubMed Central Google Scholar Mikasova, L. et al. Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. Brain 135, 1606–...
N-methyl-d-aspartate (NMDA) receptor antibody encephalitis, since its description in 2007, has emerged as one of the most common causes of encephalitis among young people in the developed world [1]. While up to a third of cases of NMDA receptor antibody encephalitis are associated with an ov...
The discovery of neuropsychiatric conditions, such as anti-NMDAR encephalitis, in which NMDAR-IgG cause a severe hypofunction of NMDAR-mediated signaling that gives rise to a combination of psychiatric and neurological manifestations without altering channel gating,19,36,59 further fed this new field ...
we need to determine where and when functional down-regulation of NMDARs occurs endogenously. Research on uncompetitive NMDAR antagonist-induced psychosis and on anti-NMDAR encephalitis, which often causes schizophrenia-like psychosis, has provided some important clues. However, a more straight-forward ...
Nonpathogenic cellular prion protein (PrPC) was previously reported to demonstrate anti-inflammatory activity in a variety of contexts, including in experimental autoimmune encephalitis and in ischemic brain injury ((108) for review). LRP1 functions as a receptor for nonpathogenic cellular PrPC (109–...