[8] Jeskey J, Parida A, Graven K, et al. Novel gene deletion in NLRC4 expanding the familial cold inflammatory syndrome phenotype[J]. Allergy Rhinol (Providence), 2020,11:2152656720928062. DOI: 10.1177/2152656720928062....
Results. Compared with the TT genotype at the NLRC4 gene rs385076 locus, the mortality of HLH patients with TC genotype and CC genotype was higher (RR = 3.205 , 95% CI: 1.277-4.788, p = 0.012 ; RR = 3.052 , 95% CI: 1.098-4.753, p = 0.031). Taking the CC genotype at rs4...
(-20℃) 相关类别: 抗原 概述: Fusion protein corresponding to a region derived from 501-700 amino acids of human NLRC4 技术规格: Full name: Synonyms: Swissprot: Gene Accession: Purity: Expression system: Tags: Background: NLR family CARD domain containing 4 CLAN; IPAF; AIFEC; CLAN1; C...
该NLRC4 Polyclonal Antibody. This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stres
Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. Applications: ELISA, IHC Name of antibody: NLRC4 Immunogen: Fusion protein of human NLRC4 Full name: NLR family CARD domain containing 4 Synonyms: CLAN; IPAF...
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enteroco...
摘要 革兰氏阴性致病菌的鞭毛蛋白以及三型分泌系统基座蛋白激活NLRC4 炎症小体的生化机制研究 哺乳动物的巨噬细胞、树突状细胞是宿主先天性免疫反应的重要组成部分。在 细菌感染发生时,这些细胞通过分泌各种细胞因子以及发生一种以Caspasel激活 为特征的被称为“pyroptosis"的细胞死亡来抑制细菌的繁殖散布,帮助细菌的清...
CLAN, a novel human CED-4-like gene Genomics (2001) B.J. Geddes et al. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis Biochem Biophys Res Commun (2001) M. Lamkanfi et al. Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1...
Knockout of the NLRC4 gene using the clustered regularly interspaced short palindromic repeat/Cas9 system in a mutant iPSC clone abrogated the pathogenic phenotype. Conclusion: Our findings indicate that the patient has somatic mosaicism of a novel NLRC4 mutation. To our knowledge, this is the ...
The NLRC4 inflammasome mediates the rapid release of proinflammatory cytokines in response to various microbial stimuli, but its role in the pathology of diseases remains unknown. Two new studies now report gain-of-function mutations in the NLRC4 gene that cosegregate with distinct autoinflammatory ...