因为NONMEM和很多其它的软件都是收费的,只能用R上开源的一些package比如nlme和基于nlme比较新的nlmxir2. nlmixr is a free and open-source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK-PD, and quantitative systems pharmacology mixed-effects models. Currently, nlmixr...