The triggering of NK cells is regulatedby both activating and inhibitory surface receptors.However, the absence or disparity of MHC-class I is not sufficient to promote NK cell killing and requires the appropriate expression of activating receptors such as Natural Cytotoxic Receptors (NCRs), 2B4 and...
A. Zloza, et al. Engagement of NK receptor NKG2D, but not 2B4, results in self-reactive CD8+ T cells and autoimmune vitiligo Autoimmunity, 44 (8) (2011), pp. 599-606 CrossrefView in ScopusGoogle Scholar Cited by (4) Co-expression of IL-4/IL-15-based inverted cytokine receptor in ...
Molecular characterizations of activating receptor complexes such as NGK2D-DAP10 and 2B4-SAP have also underscored the potential of receptor complexes without ITAM motifs to stimulate granule release and cell-mediated cytotoxic- ity. For NKG2D-DAP10, the phosphatidylinositol 3-kinase (PI3K)- binding ...
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence. PLoS Pathog. 2012, 8, e1002594. [CrossRef] [PubMed] 68. Roda-Navarro, P.; Reyburn, H.T. The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell...