目前用于细胞治疗的NK细胞,主要来自于NK细胞系、供体外周血或脐带血NK细胞、以及诱导多能干细胞分化得到的NK细胞(iPSC-NK)。由于NK细胞本身存在多种生物学亚组分型,具有不同的抗肿瘤细胞活性,因而NK细胞存在较大的异质性,这限制了NK...
Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8+T cells and have both activating and inhibi...
Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins. Natural killer (NK) receptors are expressed in both NK cells and cytotoxic CD8+T cells and have both activating and inhibitory ...
NKG2C+ NK cells express IFN-γ in response to NKG2C engagement.Merlin LuetkeEverslohQuirin HammerPawel DurekKarl NordstromGilles GasparoniMatthias PinkAlf HamannJörn WalterHyunDong ChangJun Dong
Among innate cells, natural killer (NK) cells play a crucial role in the defense against cytomegalovirus (CMV). In some individuals, CMV infection induces the expansion of NKG2C+ NK cells that persist after control of the infection. We have previously shown that KIR2DL+ NK cells, in ...
c is used as a receptor for NK cells and some cytotoxic T cells to recognize MHC class I HLA-E molecules. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells....
The CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E is coupled to the KARAP/DAP12 adapter in a subset of NK cells, triggering their effector functions. We have studied the distribution and function of this KLR in T lymphocytes. Like other NK cell receptors (NKR), CD94/...
NK Cells Respond Specifically to Acute Infection with Cytomegalovirus and Not Epstein–Barr Virus CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activating CD94-NKG2C receptorthat persist after control of the infection. We investigated whether this subset...
NK cells Anti-NKG2C抗体preferentially express several calcium dependent (C type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins ...
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been...