Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC/p38MAPK/NFκB Pathway After Experimental Intracerebral Hemorrhage in MiceHematoma clearanceIntracerebral hemorrhageMicroglia polarization...
Aprepitant is a specific NK-1R antagonist, used as an antiemetic agent. CAS# 170729-80-3 2D Structure Catalog No. BCC1101---Order now to get a substantial discount! Product Name & SizePriceStock Aprepitant: 5mg $92 In Stock Aprepitant: 10mg Please Inquire In Stock Aprepitant: 20mg Please...
PurposeAntiemetic guideline recommendations are inconsistent as to whether a neurokinin-1 receptor antagonist (NK1 RA) should be administered with a 5-hydroxytryptamine-3 (5HT3) RA + dexamethasone (DEX) in patients receiving carboplatin. Patients receiving cisplatin routinely receive an NK1 RA-conta...
Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC/p38MAPK/NFκB Pathway After Experimental Intracerebral Hemorrhage in Mice 2021, Neurotherapeutics Citation Excerpt : The fact that inhibition of NK1R can exert neuroprotective effects ...
Conclusion: The NK-1R receptor antagonist aprepitant acts as an anti-inflammatory agent, indicating that the blockage of the NK-1R pathway in macrophages has the potential to suppress inflammation.doi:10.2147/DDDT.S244099Xiao-nan ZhaoZhen-zi Bai...
Aprepitant, a NK-1R antagonist could be employed for cytotoxic therapy induced alimentary tract mucosal inflammationAnimalsJejunal DiseasesFluorouracilReceptors, Serotonin, 5-HT3Receptors, Neurokinin-1MaleMucositisObjective: Urban-rural variation in cancer incidence, treatment, and clinical outcomes has been ...
We have conducted in vitro, animal and clinical studies of the neurokinin 1 receptor (NK1R) antagonist aprepitant in HIV/SIV infection. Aprepitant inhibits HIV infection of human macrophages ex vivo with an ED50~ 5 µM. When administered at 125 mg once daily for 12 months to SIV...
NK1R antagonist, aprepitant blocks SP-induced blebs, intracellular calcium increase and impedance changes.John, MeshkiSteven, D. DouglasMingyue, HuSusan, E. LeemanFlorin, Tuluc
The results of the present study highlighted the efficacy of Aprepitant, an oral antagonist of the neurokinin-1 receptor (NK1R), against both APL (NB4) and pre-B ALL (Nalm-6) cell lines; however, a differential sensitivity pattern was found in these cells. To the best of our knowledge,...
The results of the present study highlighted the efficacy of Aprepitant, an oral antagonist of the neurokinin-1 receptor (NK1R), against both APL (NB4) and pre-B ALL (Nalm-6) cell lines; however, a differential sensitivity pattern was found in these cells. To the best of our knowledge,...