The NK1R antagonist CP-99,994 alleviated dry eye symptoms and the concentrations of IL-6, IL-1尾, and TNF-伪 were significantly decreased after CP-99,994 treatment. We obtained 68 differentially expressed genes after CP-99,994 treatment by RNA sequencing and pyroptosis-related genes (Plk1, ...
This finding echoes evidence that the selective NK1R antagonist, SR140333, reverses stress-induced impairment of novel object/location recognition tests of rodents [32] and promoted inhibitory (step-through) avoidance of a footshock [33]. Furthermore, ADHD children show no evidence of learning ...
Efficacy benefit of an NK1 receptor antagonist (NK1RA) in patients receiving carboplatin: supportive evidence with NEPA (a fixed combination of the NK1 RA, netupitant, and palonosetron) and aprepitant regimensJordan K, Gralla R, Rizzi G, Kashef K Supportive care in cancer, 2016, 24(11)...
PurposeAntiemetic guideline recommendations are inconsistent as to whether a neurokinin-1 receptor antagonist (NK1 RA) should be administered with a 5-hydroxytryptamine-3 (5HT3) RA + dexamethasone (DEX) in patients receiving carboplatin. Patients receiving cisplatin routinely receive an NK1 RA-conta...
Therapeuitc effect of neurokinin-1 receptor s antagonist on lung injury of acute necrotizing pancreatitis; 目的:探讨神经激肽-1受体(NK-1R)拮抗剂对急性坏死性胰腺炎(ANP)大鼠肺损伤的作用,了解ANP时阻断该受体对肺损害是否具有保护作用。 更多例句>> 3...
In another branch of our research, we have turned our attention to yet other small molecular NK1R antagonist, L732,138 (1c, Figure 1C), which had been reported for the first time by MacLeod et al. [16]. Using this compound as a basis for the radiopharmaceutical vector has several adva...
Su1907 Co-Administration of Valproic Acid (VPA), a Histone Deacetylase Inhibitor, and a Neurokinin-1 Receptor Antagonist (NK-1RA) Reduces Intraabdominal Adhesion Formation in a Rat Surgical Model and Also Downregulates the Expression of the Early Growth Response (Egr) Genes 1 and 3 Both In ...
RAW264.7 macrophages were incubated with CS condensate (CSC) and DMSO alone or coupled with LPS and/or NK1R antagonist (aprepitant). We found that compared to DMSO, the responses of supernatant IL-1 beta, TNF-alpha, SP and nuclear NF-κB activation to: 1) CSC were increased by 2-, 11...
Conclusion: The NK-1R receptor antagonist aprepitant acts as an anti-inflammatory agent, indicating that the blockage of the NK-1R pathway in macrophages has the potential to suppress inflammation.doi:10.2147/DDDT.S244099Xiao-nan ZhaoZhen-zi Bai...
Herein, we used a well-known, small molecular NK1R antagonist, L732,138, as the basis for the radiopharmaceutical vector. First, 14 analogues of this compound were evaluated to check whether extending the parent structure with linkers of different lengths would not deteriorate the NK1R binding....