Substance P and central respiratory activity: a comparative in vitro study in NK1 receptor knockout and wild-type mice. Pfleugers 440: 446 - 451, 2000.Ptak, K., DiPasquale, E., Monteau, R., 1999. Substance P and central respiratory activ- ity: a comparative in vitro study on fetal ...
NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. 来自 EBSCO 喜欢 0 阅读量: 63 作者:T.C. Yan,A Mcquillin,A Thapar,P Asherson,H Gurling 摘要: Mice with functional genetic ablation of theTacr1(substance P-preferring receptor) gene (NK1R/) are...
In Cav-1(-/-) mice: (i) ICC were Ano1-negative but maintained c-Kit expression, (ii) NK1 and NK2 receptor immunoreactivity was more intense and, in the SMC, mainly intracytoplasmatic, (iii) SP-immunoreactivity was significantly reduced. Under TEM: (i) ICC, SMC and telocytes lacked ...
and Department of Anesthesiology, University of California at San Diego School of Medicine, San Diego, CA, USA Genetic deletion of the neurokinin 1 receptor (NK1R) has been shown to decrease the reinforcing properties of opioids, but it is unknown whether pharmacological NK1R blockade has the sa...
In the first set of experiments, NK1 receptor knockout mice failed to acquire an operant response to obtain intravenous administration of morphine, although wildtype mice readily acquired the Acknowledgements TLR and CAG contributed equally to the work reported here. TLR and DNS are supported by MR...
360 Functional expression of ORAI1/STIM1 complex has been confirmed in hippocampal astrocytes in situ in acutely isolated slices; conditional knockout of ORAI1 markedly reduced SOCE and affected astrocytic Ca2+ dynamics. Sign in to download full-size image Figure 3.31. Store-operated Ca2+ entry....
K. Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NaCl diet with/without aldosterone infusion. American journal of physiology. Renal physiology 300, F657–668 (2011). 19. Ahn, D. et al. Collecting duct-specific knockout of ...
Poly I:C can inhibit PA-induced necroptosis of UCP1−/− NK cells independent of mitophagy Given that poly I:C functions as a toll-like receptor 3 agonist, whether necroptosis of PA-treated UCP1−/− NK cells could be reversed by poly I:C ex vivo were investigated. Clearly, poly...
NK cell differentiation mainly occurs in the bone marrow (BM) where a critical role in the regulation of developing lymphocyte distribution is played by members of the chemokine receptor family. In mouse, the chemokine receptor CX3CR1 identifies a late stage of NK cell development characterized by...
Instead, the role of mitophagy in pancreatic β-cells has been investigated using β-cell-specific-knockout mice (mice);is a master regulator of lysosomal biogenesis or autophagy gene expression and participates in mitophagy.mice were unable to adaptively increase mitophagy or mitochondrial complex ...