导致呕吐中枢兴奋,引起呕吐反射。在治疗上疗效 最显著的是相应的受体拮抗剂,因此,对化疗药诱发 呕吐的受体机制研究最为人们关注。本文将该领域 研究进展综述如下。 1 化疗致急性呕吐的机制 1.1 外周性5一HT及5一H 受体 外周5一HT主要贮存于胃肠嗜铬细胞及血小 ...
O Dirat,JM Elliott,RA Jelley,AB Jones,M Reader 摘要: A stereoselective asymmetric route to novel potent NK 1 antagonists based on a 1,2,4-trisubstituted cyclohexane core is discussed.关键词:NK 1 Asymmetric synthesis Triazole α-Arylation ...
All of the HGF variants have the potential to become pharmaceutical drugs in the treatment of human cancer. Introduction It is well documented that cell dissemination is aided by the adequate vascularization of tumors, the release of cells from the primary tumor, and the adhesion of tumor cells ...
This work provides preclinical data supporting the addition of epigenetic drugs, such as guadecitabine, to ICBs to increase the number of responding patients and the duration of response.Availability of data and materials DNA-methylation microarray data are available under accession number GSE220698 at ...
After 24 h in serum-free media, the cells were treated with various drugs. To examine the stimulation of EGFR by EGF, the cells were treated with EGF (100 ng/mL) for 10 min. To examine the blockade of EGF stimulation of EGFR by erlotinib, the cells were treated with erlotinib for 1...
viruses Article Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection Shawn A. Abeynaike 1 , Tridu R. Huynh 1,2,3 , Abeera Mehmood 1 , Teha Kim 1, Kayla Frank 1, Kefei Gao 1, Cristina Zalfa 1, Angel Ganda...
Ofloxacin, Ornidazole and Metronidazole Drugs in Rat Model In the present study, the researchers have tried to determine the toxicity of a novel fixed dose combination of ofloxacin plus ornidazole (mebatic) vs. ofl... A Ahmad,M Chaudhary,A Soni,... - 《Asian Journal of Biochemistry》 被引...
Tape stripping is a common method for investigating stratum corneum (SC) physiology as well as bioavailability and bioequivalence of topical drugs. To inve... H Lffler,F Dreher,HI Maibach - 《British Journal of Dermatology》 被引量: 185发表: 2004年 Colorimetric Method for Quantifying Human Stra...
For selected drugs and years of observation, special emphasis was placed on the study of time patterns (reaction time, exposure time). A total of 1317... T Hunziker,UP Künzi,S Braunschweig,... - Allergy 被引量: 390发表: 1997年 Comparison of real-time polymerase chain reaction and serolo...