衰老与疾病与NK细胞密切相关 NK细胞在免疫系统中表现出很高的细胞毒性。更改其数量或活性可能会对整体免疫力产生深远影响。他的降低让老年人群变得更容易受到感染、患癌、自身免疫疾病和神经退行性疾病等。随着全世界老年人比例的增加,人们迫切需要更好地了解免疫系统的老化,以预防和治愈他的老化。为此,我们需要更好地...
In addition, NK cells express endothelial NO synthase and thus can constitutively produce NO (103). Most interestingly, it was recently shown that NK cells can also be a source of resolvin E1, suggest- ing that they can also contribute to the resolution phase of inflammation (104). NK ...
Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor. Cancer Immunol. Immunother. 61, 1451–1461 (2012). Article CAS PubMed Google Scholar Zhang, G. et al. Retargeting NK-92 for anti-...
Table 1Gene mutations associated with NK/T cell lymphoma [ 14 ] 3 病理诊断 ENKTL的病理学特征为弥散性浸润和血管中心性破坏性生长。肿瘤细胞围绕血管生长,浸润和破坏血管壁,最终导致片状坏死,邻近溃疡及组织坏死部位可见小血管纤维素样坏死及血管炎。部分病例肝、脾及骨髓中存在噬血细胞现象 [ 15 ]。目前研...
Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU. Cancer Immunol. Immunother. 56, 1605–1613 (2007). Article PubMed CAS Google Scholar Salmon, H. et al. Expansion and activation of CD103+ dendritic cell progenitors at the tumor site ...
This receptor is encoded by the NK gene complex and its secondary structure includes two β-sheets, two α-helices, and four disulfide bonds [20]. NKG2D bypasses signals from the negative receptor and initiates the effector function or sensitization of the NK cell upon contact with specific ...
Vectofusin-1 significantly increased NK cell transduction efficacy [31]. Alternatively, mRNA/DNA electroporation offers a versatile platform to induce gene expression in NK cells. Recently, the expansion of genetic editing techniques, such as the clustered regularly interspaced short palindromic repeats/...
For example, vesicular cationic lipid-assisted nanoparticles (CLAN) mediated gene silence efficiently downregulated LDHA expression, decreased lactate secretion, normalized the tumor acidity, increased infiltration of immune cells, and restored the anti-tumor responses of T cells and NK cells (Fig. 10A)...
These clusters expressedCD9,ITGA1/CD49a, andITGAE/CD103. Further examination of these clusters showed a common panel of differentially expressed genes, including decreased expression of cytotoxicity markers and upregulation of inhibitor checkpoints such asKLRC1/NKG2a. A gene expression signature ...
Vectofusin-1 significantly increased NK cell transduction efficacy [31]. Alternatively, mRNA/DNA electroporation offers a versatile platform to induce gene expression in NK cells. Recently, the expansion of genetic editing techniques, such as the clustered regularly interspaced short palindromic repeats/...