Natural killer (NK) cells are lymphoid cells of innate immunity that take important roles in immune surveillance. NK cells are considered as a bridge between innate and adaptive immunity, and their infiltration into tumor area is related positively with prolonged patient survival. They are defined a...
Today, three different types of NK cell memory have been described: (i) cytokine-induced memory-like cells, (ii) MCMV-induced memory, and (iii) liver-restricted NK cell memory (Fig. 5.4). Sign in to download full-size image Figure 5.4. Three forms of NK cell memory. (left panel) NK...
First comprehensive summary of the recent advances in the use of nanomaterials for enhancing NK cell-based tumor immunotherapy. • The mechanisms of NK cell activation and inhibition for immunotherapy. • Rational design and fabrication of nanomaterials to elaborately enhance NK cell-based tumor immu...
NK cell development, homeostasis and function: parallels with CD8+ T cells. Nat Rev Immunol. 2011;11:645–57. 51. Pongpruttipan T, Sukpanichnant S, Assanasen T, Wannakrairot P, Boonsakan P, Kanoksil W, et al. Extranodal NK/T-cell lymphoma, nasal type, includes cases of natural ...
Memory consolidation is a process required for the formation of long-term memories. The G-protein-coupled receptor (GPCR) neurokinin-3-receptor (Nk3R) and its interactions with sex hormones seem important for the modulation of fear memory consolidation:
NK/T-cell lymphomas as part of two studies [101,102], with only one case (20%) showing a partial response. Other drugs approved in T-cell lymphomas, including pralatrexate and romidepsin [103], had been tested in too few cases of NK/T-cell lymphomas for their efficacies to be defined...
A random forests classifier was built using the randomForest R package23. The “number of decision trees” and “mtry” parameters were set to “10,000 trees” and “square root of the total number of features”, respectively103. Finally, the gene importance measure is computed by averaging ...
Conversely, myo-inositol-trispyrophosphate (ITPP), which increases oxygen liberation by hemoglobin, has been shown to increase NK cell abundance while decreasing TREG cell numbers in the TME of experimental melanomas [103]. Similar results have been obtained with human breast cancer spheroids treated ...
(iPSCs) and NK cell lines, have been used as sources to generate NK cells for immunotherapy. Moreover, genetic modification technologies to improve the proliferation of NK cells have also been developed to enhance the functions of NK cells. Here, we summarize the recent advances in expansion ...
Several NK cell sources have been used for adoptive transfer. The NK-92 cell line has been approved for clinical application by the Food and Drug Administration (FDA) [6]. Although this cell line displays cytotoxicity against tumor cells, it has poor ADCC potential because it lacks the CD16...