In our center, the modified MINE regimen was applied to treat three patients with hemophagocytic syndrome secondary to aggressive NK cell leukemia and T-cell lymphoma. The modified MINE regimen showed good efficacy against NK/T cell lymphoma, control of the inflammatory state of secondary ...
benefits often lasted only a few months before relapse, likely due to resistance or to low NK cell persistence. NK cell persistence typically ranges from a few days to 4 months, with an average of 7 days. NK cell expansion was highly variable, with no NK cell expansion observed in some t...
benefits often lasted only a few months before relapse, likely due to resistance or to low NK cell persistence. NK cell persistence typically ranges from a few days to 4 months, with an average of 7 days. NK cell expansion was highly variable, with no NK cell expansion observed in some t...
without genetic manipulation of NK cells derived from various cellular sources. We also discuss the closed, automated and GMP-controlled large-scale expansion systems used for NK cells and possible future NK cell-based immunotherapy products. to check access....
结外NK/T淋巴细胞淋巴瘤鼻型(extranodal natural killer/T-cell lymphoma,nasal type,ENKTL)是一种少见的结外原发性非霍奇金淋巴瘤(non-Hodgkin′s lymphoma, NHL),具有高度侵袭性。常见于亚洲(如中国、日本、韩国)和中南美洲(如墨西哥、秘鲁、巴西等),东南亚地区发病率约为0.25/10万 [ 1 ]。上述地区ENKTL约占...
Today, three different types of NK cell memory have been described: (i) cytokine-induced memory-like cells, (ii) MCMV-induced memory, and (iii) liver-restricted NK cell memory (Fig. 5.4). Sign in to download full-size image Figure 5.4. Three forms of NK cell memory. (left panel) NK...
The human NK cell line NK92, which overexpresses TIM-3, shows a significant increase in IFN-γ production when paired with Gal-9 [45]. PBMC-derived NK cells show decreased cytolytic activity when treated with a TIM-3 antibody. Additionally, TIM-3 can act as a marker of NK cell ...
NK cell development, homeostasis and function: parallels with CD8+ T cells. Nat Rev Immunol. 2011;11:645–57. 51. Pongpruttipan T, Sukpanichnant S, Assanasen T, Wannakrairot P, Boonsakan P, Kanoksil W, et al. Extranodal NK/T-cell lymphoma, nasal type, includes cases of natural ...
(2). The main NK cell population of the lymph node (CD56brightCD16-) expresses low levels of NKp46 in resting cells, but expression is upregulated by IL-2. Mouse NKp46, also known as MAR-1 (3), is a type I transmembrane protein with two extracellular Ig-like domains. It has a ...
However, the effectiveness of NK cell-based immunotherapies against solid tumors remains limited (Renken et al., 2022). One major obstacle is the immunosuppressive tumor microenvironment (TME) of solid tumors, characterized by elevated levels of TGF-β, which hampers NK cell functions through ...