First comprehensive summary of the recent advances in the use of nanomaterials for enhancing NK cell-based tumor immunotherapy. • The mechanisms of NK cell activation and inhibition for immunotherapy. • Rational design and fabrication of nanomaterials to elaborately enhance NK cell-based tumor immu...
Natural killer (NK) cell-based immunotherapy has been considered a promising cell-based cancer treatment strategy with low side effects for early tumors and metastasis. However, the therapeutic efficacy is generally low in est...
2023年9月,河南郑州大学研发团队在《Biomedicine & Pharmacotherapy》期刊上发表了一篇论文:Driving natural killer cell-based cancer immunotherapy for cancer treatment: An arduous journey to promising ground,该研究综述了几种方法来增强NK细胞的抗肿瘤活性,且已经进入临床阶段。 图源:参考资料2(下同) 方法一:NK细...
Presently, NK cell-based tumor immunotherapy strategies encompass various approaches, including adoptive NK cell therapy, cytokine therapy, antibody-based NK cell therapy (enhancing ADCC mediated by NK cells, NK cell engagers, immune checkpoint blockade therapy) and the utilization ...
Overall, receptor engineering has led to significant advances in NK cell-based cancer immunotherapies. As technical challenges are addressed, these innovative treatments will likely reshape cancer immunotherapy. In recent decades, adoptive cell therapies have emerged as promising approaches for harnessing the...
近几年,自然杀伤细胞(Natural killer cell,NK)成为抗肿瘤免疫的焦点,也成为国自然的热点。本期,我们通过2022年7月份发表在Pharmacology & Therapeutics上的一篇综述,解读NK细胞的基本信息。 1.肿瘤微环境概述 肿瘤微环境(The tumor microenvironment,TME)是一个复杂的生态...
此外,【T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion】证明了利用原代人NK细胞进行TCR基因治疗是可能的。研究发现,原代NK细胞可以成功地用TCRα/β链进行基因修饰,同时添加CD8α/β共受体和包括所有四条CD3链的完整CD3复合体。提出了一种两步逆转录病毒...
Natural killer (NK) cells have crucial roles in tumor surveillance. We found that tumor-infiltrating NK cells in human liver cancers had small, fragmented mitochondria in their cytoplasm, whereas liver NK cells outside tumors, as well as peripheral NK cells, had normal large, tubular mitochondria...
From:NK cell-based cancer immunotherapy: from basic biology to clinicaldevelopment ▉ 过继性 NK 细胞疗法 过继性 NK 细胞疗法的一个有希望的途径是使用嵌合抗原受体(CARs)。CAR,通常编码在慢病毒构建体中,由三个主要结构域组成:细胞外抗原靶向结构域(胞外结构域)、跨膜区和一个或多个细胞内信号传导域。靶点...
kills cancer cells in vitro and suppresses tumor growth in vivo. The ideal BH3 mimetic to use in such an approach can be predicted by BH3 profiling. We herein report a rational and precision strategy to augment NK-based immun...