(SLE) in patients with or without lupus nephritis and in an investigator-initiated basket trial in multiple autoimmune indications. In addition, AlloNK is being evaluated for the treatment of non-Hodgkin lymphoma, as well as in combination with Affimed’s innate cell engager acimtamig for the ...
thereby augmenting their anti-tumor efficacy. For example, Wing et al. designed folate receptor alpha (FR-α) targeting T cell engager CAR-T cells (anti
thereby augmenting their anti-tumor efficacy. For example, Wing et al. designed folate receptor alpha (FR-α) targeting T cell engager CAR-T cells (anti
[48]. This tight regulation is required to avoid autoimmune diseases, excessive inflammation, or immune-related damage. Although NK cells have been extensively investigated for almost half a century, this complex process of NK cell activation is still not completely understood. Many things contribute...
Similar to BiTe (i.e., bispecific single-chain T-cell engager, such as Blinatumomab that couples anti-CD3 to anti-CD20), BiKe are composed of a single-chain variable fragment (scFv) of an antibody specific for a given TAA connected through a short peptide linker to an anti-CD16 scFv, ...
Modulating HRS-NK interactions to unleash NK cell cytolysis is being explored and combined with PD-1 blockade. AFM13 is a CD30/CD16A bispecific antibody acting as an innate immune engager. It creates a bridge between CD30, expressed on HRS cells, and the activating receptor CD16A, expressed...