Jie HB, Sarvetnick N. The role of NK cells and NK cell receptors in autoimmune disease. Autoimmunity 2004;37:147-53.Jie HB and Sarvetnick N. The role of NK cells and NK cell receptors in autoimmune disease. Autoimmunity. 2004; 37(2):147-153....
[10] Mandal, Arundhati, and Chandra Viswanathan. "Natural killer cells: In health and disease." Hematology/oncology and stem cell therapy 8.2 (2015): 47-55.
[10] Mandal, Arundhati, and Chandra Viswanathan. "Natural killer cells: In health and disease." Hematology/oncology and stem cell therapy 8.2 (2015): 47-55.
Calvo-Pérez, A., Oñate, C., ... & Pardo, J. (2022). All about (Nk cell-mediated) death in two acts and an unexpected encore: Initiation, execution and activation of adaptive immunity. Frontiers in Immunology, 13, 896228.
[10] Mandal, Arundhati, and Chandra Viswanathan. "Natural killer cells: In health and disease." Hematology/oncology and stem cell therapy 8.2 (2015): 47-55.
在一篇题为“Targeting natural killer cell reactivity by employing antibody to NKp46: implications for type 1 diabetes”研究中,科学家发现NK细胞激活受体NKp46在1型糖尿病的发展中发挥着重要作用。NKp46与胰岛素分泌β细胞表面表达的配体结合,导致这些细胞遭到破坏。
图2:NK细胞在体内的分布和各器官中的亚群占比(图来自CELL) NK 细胞可以通过多种机制杀伤靶细胞。NK细胞的功能包括脱颗粒、释放细胞因子和细胞毒性,受激活受体(油门)和抑制受体(刹车)信号的整合控制。在机体中,NK细胞可以通过“缺失自我”的机制杀伤靶...
Artiva Biotherapeutics is a cell therapy company with the ability to produce highly scaled, off-the-shelf, allogeneic NK cell therapies.
Quantitative and Functional Analysis of PD-1+ NK Cells in Patients With Autoimmune Thyroid Disease The role of NK cells expressing the programmed cell death protein-1 (PD-1) regulatory receptor has not been explored in patients with autoimmune thyroid ... ORA Cesleste,MH Rebeca,MU Adriana,.....
该研究使用三基因修饰的诱导多能干细胞(induced pluripotent stem cell, iPSC)来源的自然杀伤iNK细胞产物,统称为iDuo NK细胞,其表达CD19 嵌合抗原受体(chimeric antigen receptor, CAR)能够提供精准靶向;IL-15RF能够增强效应持久性,使其不...