single enzyme transforms a carboxylic acid into a nitrile through an amide Intermediate. Angew Chem Int Ed Engl 2015; 54:10627-10629; PMID:26228534; http://dx.doi.org/ 10.1002/anie.201504505Nelp, M.T.; Bandarian, V. A single enzyme transforms a carboxylic acid into a nitrile through an...
Hydrolysis of nitrile functionality has been a crucial synthetic approach to produce important amides and carboxylic acids, since it also allows for carbon chain extensions. Chemically, the hydrolytic reaction proceeds in an aqueous medium to yield carboxylic acid via amide formation; however, the react...
O, and finally liberated the carboxylic acid along with the regenerated enzyme. On the same year, Hook and Robinson demonstrated that a similar mechanism was also responsible for the ricinine hydrolysis through the ricinine nitrilase[28]. The proposed mechanism has been widely accepted by ...
By systematically varying reaction parameters, we elucidate the transformation mechanism of nitriles to carboxylic acids. Results indicate that nitriles are effectively converted into the corresponding amides in pure MSA, while carboxylic acids (up to 80%) in MSA/H 2 O mixtures. Characterization ...
Herein, we present a new, efficient and convenient one-pot procedure for conversion of carboxylic acids into nitriles by their treatment with acetonitrile in presence of conc. sulfuric acid. The general preparative value of this reaction will be presented and the mechanism of the reaction will be...
Mild and selective hydrolysis of a large range of nitriles leading to carboxylic acids was achieved under neutral conditions by an immobilized and genetica... P Rey,JC Rossi,J Taillades,... - 《Journal of Agricultural & Food Chemistry》 被引量: 68发表: 2004年 Hydrolysis of Nitriles Using ...
Initially the oxime behaves like an enol and reacts with chlorine on carbon. Subsequent loss of a proton leads to the chloroxime. This is an example of γ-elimination. There are two key steps in the formation of the nitrile oxide: the removal of the OH proton by base and the loss of...
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nitrilase to catalyze the hydrolysis of benzonitrile derivatives directly into the corresponding carboxylic acid and ammonia; Evaluation of the performance of the nitrile sensor by adding ammonium chloride to the buffer solution.LiuZhaohuiWangYiEBSCO_AspAnalytical Chemistry...
Currently, it has important applications as ionic elastomer [1], damping materials [2], self-crosslinking film [3], polymer composites and blends [4], and so on, owing to its unique chemical structure. XNBR contains different active functional groups, including carboxylic, nitrile and alkene ...