Nickel-Catalyzed Arylcyanation of Alkynes. Y. Nakao,S. Oda,T. Hiyama. Journal of the American Chemical Society . 2004Nakao, et al., " Nickel-Catalyzed Arylcyanation of Alkynes ", Journal American Chemical Societ
Nakao Y,Hirata Y,Tanaka M,Hiyama T.Nickel/BPh3-Catalyzed Alkynylcyanation of Alkynes and 1,2-Dienes:An Efficient Route to Highly Functionalized Conjugated Enynes. Angew. Chem., Int. Ed . 2008Nakao, Y,Hirata, Y,Tanaka, M. et al.Nickel/BPh3-catalyzed alkynylcyanation ofalkynes and 1,2-...
Table 1 Optimization of the reaction conditionsa. Substrate scope With the optimized coupling conditions in hand, the scope of alkynes was first evaluated using1aas the coupling partner. For some cases that the products were unseparated from the excess terminal alkynes,p-methoxylphenethylpyridinium sa...
A nickel catalyst prepared from Ni(cod) 2 and PMe 3 is found to effect arylcyanation reaction of alkynes, namely, cleavage of a C–CN bond of an aryl cyanide followed by addition of each fragment across an alkyne. A wide range of functional groups in aryl cyanides tolerated the catalysis...
Recently, nickel-catalyzed cleavage and addition reaction of aryl-CN bonds across alkynes were reported by Nakao et al. Various beta-arylsubstituted acrylonitrile derivatives are effectively produced by this reaction. When the alkyne was not symmetric, stereoselectivity was observed in the product, as ...
Alkynes undergo aryl- and allylcyanation reaction in the presence of nickel-phosphine catalysts to give a wide range of substituted acrylonitriles in highly stereo-, regio-, and chemoselective manners. Lewis acid cocatalysts, such as AlMe3, AlMe2Cl, and BPh3, are found to promote the aryl...
Lewis-acid catalysts such as AlMe3, AlMe2Cl, and BPh3 significantly improve the efficiency of the nickel-catalyzed arylcyanation of alkynes. Electron-rich aryl cyanides, which exhibit poor reactivity in the absence of Lewis acids, readily undergo the arylcyanation reaction under the newly ...
Nickel/BPh 3 -catalyzed alkynylcyanation of alkynes and 1,2-dienes: An efficient route to highly functionalized conjugated enynes. Nakao, Yoshiaki,Hirata, Yasuhiro,Tanaka, Masaaki,Hiyama, Tamejiro. Angewandte Chemie - International Edition . 2008...
nickelC-C bond activationnitrilealkyneC BOND-CLEAVAGECARBON-CARBON BONDSOXIDATIVE ADDITIONNICKEL(O)-CATALYZED REACTIONSELECTIVE SYNTHESISCRYSTAL-STRUCTURESNo Abstractdoi:10.1016/J.TET.2006.02.086Nakao, Y.Oda, S.Yada, A.Hiyama, T.TETRAHEDRON -LONDON-...
CarbocyanationC–C bond activationAlkyneDieneAlkynyl cyanides are found to add across alkynes and 1,2-dienes in the presence of a catalyst prepared in situ from Ni(cod) 2, xantphos, and BPh 3. A range of functionalized conjugated cis-enynes are obtained with high regioselectivity. The ...