A number of cell surface receptors, activated by niche-derived ligands such as THPO-MPL, DARC-CD82, or Histamine-H2R, have been described to directly modulate HSC behaviour28,29,30,31. Interestingly, some of these, including CXCR4-CXCL12 (C-X-C chemokine receptor type 4/C-X-C motif ch...
Thus, a nonribosomal, monoamine-derived peptide provided by niche cells acts as a critical signal to trigger planarian reproductive development. These findings reveal an unexpected function for monoamines in niche-germ cell signaling. Furthermore, given the recently reported role for BATT as a male-...
Vascular Niche-Derived Angiocrine Factors Specify and Maintain Hematopoietic Stem Cells 来自 ResearchGate 喜欢 0 阅读量: 29 作者:S Rafii,JM Butler,G Michael,JL Gori,S Jospeh 摘要: Organ-specific endothelial cells (ECs) are both conduits for delivery of nutrients and also establish an instructive ...
Characteristics of hADMSC derived NS: Phase-contrast Micrographs of NS derived from hADMSCs. (a) Fibrin niche fiber morphology and porosity (10,000x magnification); (b) Mature NS by day 7 in bare TCPS (INB); (c) Mature NS by day 7 in fibrin niche (INF); (d) Graphical representation...
Furthermore, miR-21 expression in plasma-derived sEVs was positively correlated with liver metastasis in CRC patients. Collectively, our data demonstrate a pivotal role of CRC-sEVs in promoting liver metastasis by inducing an inflammatory pre-metastatic niche through the miR-21-TLR7-IL6 axis. ...
Tumor-derived exosomes carry proteins, lipids, and various nuclear acids that promote increased permeability of the vascular endothelial barrier, ultimately inducing CRC hematogenous metastasis and pre-metastatic niche formation [12]. Our preliminary clinical studies revealed elevated levels of exosome-...
AIM: To investigate the expression of Hedgehog signaling pathway in the mesenchymal stem cells derived from human limbal niche( LNCs).METHODS: Culture and ... J Wang,GG Li,F Li,... 被引量: 0发表: 2015年 Bone Marrow derived Mesenchymal Stem Cells for Reconstructing the Limbal Niche In pati...
Recent studies have indicated that the hematopoietic stem/progenitor cell (HSPC) niche, consisting of two major crucial components, namely osteoblasts (OBs) and mesenchymal stromal cells (MSCs), is responsible for the fate of HSPCs. Thus, closely mimicking the HSPC nicheex vivomay be an efficient...
A life cycle assessment of biodiesel derived from the 'niche filling' energy crop camelina in the USA 来自 掌桥科研 喜欢 0 阅读量: 1 作者:Brian J. Krohn,Matthias Fripp 摘要: Camelina sativa (L.) is a promising crop for biodiesel production that avoids many of the potential pitfalls of ...
Myeloid-derived suppressor cells (MDSCs) are essential for premetastatic niche formation, and may persist in distant organs for up to 2 weeks after surgery. These postsurgical persistent lung MDSCs exhibit stronger immunosuppression compared with presurgical MDSCs, suggesting that surgery enhances MDSC...