Sneddon JB. The contribution of niche-derived factors to the regulation of cancer cells. Methods Mol Biol. 2009; 568 :217–32.Sneddon JB (2009). The contribution of niche-derived factors to the regulation of cancer cells. Methods Mol Biol 568, 217-232....
A number of cell surface receptors, activated by niche-derived ligands such as THPO-MPL, DARC-CD82, or Histamine-H2R, have been described to directly modulate HSC behaviour28,29,30,31. Interestingly, some of these, including CXCR4-CXCL12 (C-X-C chemokine receptor type 4/C-X-C motif ch...
[83]. Endothelial cell–derived factors play key roles in maintaining the stem cell phenotype in these tissues [72]. In the meantime, the metastatic cancer cells are observed closely associated with perivascular sites in breast cancer, lung cancer, and melanoma metastasis processes [39,84]. Both...
et al. Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma. Cancer Res. 76, 1089–1100 (2016). CAS PubMed PubMed Central Google Scholar Terpos, E. et al. Circulating activin-A ...
which are enriched above the typical concentration found in blood. This growth factor “stew” is hoped to have some therapeutic or even regenerative benefits. As a cell biologist, I can see some logic in the potential use of a concentrated prep of a patient’s own growth factors. The key...
Here, we show that tumor ECs supply angiocrine factors to promote chemotherapy resistance and extranodal invasiveness of CD44+IGF1R+CSF1R+ LCs. LCs produce FGF4 to induce expression of Notch ligand Jag1 in ECs. In turn, EC-derived angiocrine Jag1 activates Notch2 in LCs to promote tumor ...
Whilst there is emerging evidence that subtle variation in soil hydrology represents a fundamental fine-scale niche axis within plant communities, this is largely derived from studies of soil hydrology in isolation from other environmental factors.We assessed the comparative importance of fine-scale ...
while Wnt/β-catenin signaling promotes HFSC activation and maintains HF growth [17,28,37,38,39,40]. Moreover, the TGF-β2, Foxp1 and oncostatin M signaling pathways have also been shown to regulate hair cycle [16,29,37,41] . Factors that are able to tilt the balance of Wnt/β-cat...
Surgical resection and postoperative premetastatic niche. Under tumor-bearing conditions, primary tumors secrete cytokines, including growth factors, chemokines that mobilize and recruit MDSCs into the tumor microenvironment. During the progression of primary tumors, tumor-derived secretory factors and exosome...
Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can be primed and established through a complex interplay among primary tumor-derived factors, tumor-mobilized bone marrow-derived cell...