Niche-derived paracrine factors regulate normal and malignant hematopoietic stem cell fatedoi:10.1016/j.exphem.2016.06.026SDOSExperimental Hematology
Vascular Niche-Derived Angiocrine Factors Specify and Maintain Hematopoietic Stem Cells 来自 ResearchGate 喜欢 0 阅读量: 31 作者:S Rafii,JM Butler,G Michael,JL Gori,S Jospeh 摘要: Organ-specific endothelial cells (ECs) are both conduits for delivery of nutrients and also establish an instructive ...
[83]. Endothelial cell–derived factors play key roles in maintaining the stem cell phenotype in these tissues [72]. In the meantime, themetastatic cancercells are observed closely associated with perivascular sites in breast cancer, lung cancer, andmelanoma metastasisprocesses [39,84]. Both stem...
et al. Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma. Cancer Res. 76, 1089–1100 (2016). CAS PubMed PubMed Central Google Scholar Terpos, E. et al. Circulating activin-A ...
(BM) microenvironment undergoes remodelling upon ageing and contributes to functional decline of HSCs23,24,25. Still, the crosstalk between extrinsic niche-derived and HSC intrinsic factors mediating stem cell maintenance and quiescence, particularly in the context of ageing, remains elusive26,27. ...
Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can be primed and established through a complex interplay among primary tumor-derived factors, tumor-mobilized bone marrow-derived cell...
while Wnt/β-catenin signaling promotes HFSC activation and maintains HF growth [17,28,37,38,39,40]. Moreover, the TGF-β2, Foxp1 and oncostatin M signaling pathways have also been shown to regulate hair cycle [16,29,37,41] . Factors that are able to tilt the balance of Wnt/β-cat...
Several factors (e.g. climate, geology) promoted development of this diversity at different temporal and geographic scales, such as the Messinian Salinity Crisis and the onset of a Mediterranean-type climate ~3.2 Ma [4]. Glaciations during the Pleistocene (~2.6 – 0.02 Ma) also played a role...
9). CD45, a commonly used marker of bone marrow-derived immune cells, has several splicing isoforms. The CD45RO isoform is a marker of activated and memory T cells as well as activated B cells with highly mutated B-cell receptors (BCR)29,30. In the context of macrophages, CD45RO was...
the correlation was often negative. Because databases contain a majority of samples from animal-associated and marine habitats with relatively low α diversity (Fig.4c), and because genome size estimates are often based on cultivated microorganisms that differ markedly from environmentally derived genomes...