Accordingly, genetic engineering of NGR-TNF with the N-terminal serine produced a more stable and homogeneous drug (called S-NGR-TNF) with improved antitumor activity in tumor-bearing mice, either when used alone or in combination with chemotherapy. In conclusion, the targeting domain of NGR–...
Heerschap A, Fiedler W, Marreaud S, et al. A phase I study of NGR-TNF, a novel vascular targeting agent, in patients with refractory solid tumors (EORTC 16041); ASCO Annual Meeting; 2007.van Laarhoven H, Fiedler W, Desar IM, van Asten S, Marreaud S, Belli R, Bordignon C, ...
NGR-TNF is targeted to the tumour vasculature by the CNGRC peptide motif (Arap et al, 1998; Curnis et al, 2000) that specifically interacts with the CD13 (aminopeptidase N) expressed by endothelial cells of angiogenic vessels (Pasqualini et al, 2000; Curnis et al, 2002a; Buehler et al...
Dynamic contrast enhanced MRI of solid tumors and healthy tissue during treatment with NGR-TNF, a novel vascular targeting agentvan Laarhoven, Hvan Asten, JDesar, IRizzardi, GBordignon, CPunt, Cvan Herpen, CHeerschap, A
NGR-hTNF is a vascular targeting agent that consists of a modified form of human TNF-α fused with an NGR peptide. The NGR peptide moiety of the compound acts by selectively targeting blood vessels, where TNF is released, resulting in the destruction of the tumor's blood supply and subseque...
Methods: Patients (pts) with advanced MPM were treated with low-dose NGR-hTNF given at 0.8 碌g/m2 as 1-hour intravenous infusion every 3 weeks (q3w). This dose was previously selected in phase I trial based on dynamic imaging changes and preliminary clinical activity. The trial had a 2...
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NGR-TNF is a vascular-targeting agent in advanced clinical development, coupling the CNGRCG angiogenic vessel-homing peptide with tumour necrosis factor-alpha (TNF). We investigated whether NGR-TNF mobilises host BMDCs and growth factors.Methods: Blood was obtained from Lewis lung carcinoma and 4T1...
Targeted delivery of TNF to tumour vessels has been achieved by coupling this protein with the CNGRC peptide, an aminopeptidase N (CD13) ligand that targets the tumour neovasculature.The so-called NGR-TNF enhances the penetration of chemotherapeutic drugs in tumours and improves their efficacy. ...