NFKBIA、NFKB1基因多态性与冠心病及血浆IL.docx,NFKBIA、NFKB1基因多态性与冠心病及血浆IL NFKBIA和NFKB1是编码核转录因子B(NF-κB)信号通路的重要基因。NF-κB信号通路在免疫、细胞增殖和凋亡等方面都起着重要的作用。许多研究表明,NFKBIA和NFKB1的多态性与很多复杂疾病
基因名:NFKBIA 别名:IKBA,MAD-3,NFKBI,EDAID2 基因ID:4792 Chromosome: (GRCh37)14Start:35870716End:35873960Strand: 信号通路:免疫相关炎症相关凋亡抑制 NFKBIA 基因突变与药物 请后查看 NFKBIA基因突变 详细信息。
基因又名: EDAID2,IKBA,MAD-3,NFKBI Gene ID: 4792 种属 Homo sapiens 基因序列编号: NM_020529.3 基因描述 Homo sapiens NFKB inhibitor alpha (NFKBIA), mRNA DNA编码区: atgttccaggcggccgagcgcccccaggagtgggccatggagggcccccgcgacgggctg aagaaggagcggctactggacgaccgccacgacagcggcctggactccatgaaagacgag ga...
(NFKB inhibitor alpha) 该基因编码NF-Kappa-B抑制剂家族的一个成员,该家族包含多个Ankrin重复结构域。编码蛋白与rel二聚体相互作用,抑制参与炎症反应的nf-kappa-b/rel复合物。编码蛋白通过核定位信号和crm1介导的核输出在细胞质和细胞核之间移动。在外胚层发育不良伴T细胞免疫缺陷常染色体显性遗传病的无汗症患者中...
万方数据 Association study between the human NFKBIA, NFKB1 gene Polymophism, coronary artery disease and Plasma IL-6 levels A Dissertation Submitted to Xinjiang Medical University In Partial Fulfillment of the Requirements For the Degree of Doctor of Medicine By Lai Hong-Mei (Cardiology) ...
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM...
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM...
Official Full NameNFKB inhibitor alpha SynonymsIKBA; MAD-3; IkappaBalpha Location14q13.2 Gene Typeprotein-coding gene Uniprot IDP25963 Pathway/LibraryApoptosis Pathway Library; Diabetes Related Genes Library Gene SummaryNFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), ...
NFKB1NFKBIA腦血管疾病是台灣十大死因的第三位,其中有70%為缺血性中風.缺血性中風的發生是因為血管內的血栓流經狹窄的腦血管中,阻塞了某部分腦細胞的血流,使腦細胞造成缺氧性壞死.缺血性中風中最主要的危險因子之一就是動脈粥狀硬化,動脈粥狀硬化不僅會造成血管內徑變窄,影響血流順暢,其粥狀硬化的斑塊也可能脫落...
NFkB inhibitor alpha downregulates the activity of NFkB. In previous studies the NFKBIA 3'UTR AA genotype was associated with CD, while the NFKB1–94ins/delATTG mutation increased the risk for UC. Our aim was to study the above polymorphisms and patients' response to medical therapy and/or...