NFKBIA、NFKB1基因多态性与冠心病及血浆IL.docx,NFKBIA、NFKB1基因多态性与冠心病及血浆IL NFKBIA和NFKB1是编码核转录因子B(NF-κB)信号通路的重要基因。NF-κB信号通路在免疫、细胞增殖和凋亡等方面都起着重要的作用。许多研究表明,NFKBIA和NFKB1的多态性与很多复杂疾病
基因又名: EDAID2,IKBA,MAD-3,NFKBI Gene ID: 4792 种属 Homo sapiens 基因序列编号: NM_020529.3 基因描述 Homo sapiens NFKB inhibitor alpha (NFKBIA), mRNA DNA编码区: atgttccaggcggccgagcgcccccaggagtgggccatggagggcccccgcgacgggctg aagaaggagcggctactggacgaccgccacgacagcggcctggactccatgaaagacgag ga...
该基因编码NF-Kappa-B抑制剂家族的一个成员,该家族包含多个Ankrin重复结构域。编码蛋白与rel二聚体相互作用,抑制参与炎症反应的nf-kappa-b/rel复合物。编码蛋白通过核定位信号和crm1介导的核输出在细胞质和细胞核之间移动。在外胚层发育不良伴T细胞免疫缺陷常染色体显性遗传病的无汗症患者中发现了该基因的突变。[由...
(NFKB inhibitor alpha) 该基因编码NF-Kappa-B抑制剂家族的一个成员,该家族包含多个Ankrin重复结构域。编码蛋白与rel二聚体相互作用,抑制参与炎症反应的nf-kappa-b/rel复合物。编码蛋白通过核定位信号和crm1介导的核输出在细胞质和细胞核之间移动。在外胚层发育不良伴T细胞免疫缺陷常染色体显性遗传病的无汗症患者中...
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM...
Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM...
万方数据 Association study between the human NFKBIA, NFKB1 gene Polymophism, coronary artery disease and Plasma IL-6 levels A Dissertation Submitted to Xinjiang Medical University In Partial Fulfillment of the Requirements For the Degree of Doctor of Medicine By Lai Hong-Mei (Cardiology) ...
總結以上,本篇研究發現PPARγ基因多形性與缺血性中風的發生有相關性,而其風險與糖尿病存在累乘協同效應,而與高血壓存在加成協同效應.NFKB1 -94 ins/del與糖尿病則是對罹患缺血性中風的危險性存在累乘協同作用的關係.邱惠雯臺北醫學大學臺北醫學大學公共衛生學系暨研究所學位論文...
(IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5...
NFkB inhibitor alpha downregulates the activity of NFkB. In previous studies the NFKBIA 3'UTR AA genotype was associated with CD, while the NFKB1–94ins/delATTG mutation increased the risk for UC. Our aim was to study the above polymorphisms and patients' response to medical therapy and/or...