SAS-induced decrease in the p62 protein levels may be the result of degradation through autophagy. SAS induced the inhibition of NF-kappa B signaling and apoptosis at least partly via a p62-dependent effect in U251 cells. Collectively, our data shed light on the link between p62 and the NF...
These observations define a novel pathway for the activation of NF-κB involving the aPKCs and p62. Consistent with this model, the expression of a dominant-negative mutant λ/ιPKC impairs RIP-stimulated NF-κB activation. In addition, the expression of either an N-terminal aPKC-binding ...
关键词: atypical PKCs NF- B apoptosis inflammation cancer p62/Sequestosome Par4 Th2 polarization asthma DOI: 10.1038/sj.cdd.4401823 被引量: 86 年份: 2006 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Nature Nature (全网免费下载) AACR ResearchGate (全网免费下载) ResearchGate 查看更...
p62 regulates CD40-mediated NFkappaB activation in macrophages through interaction with TRAF6. Biochem. Biophys. Res. Commun. 464, 330-335, doi:10.1016/j.bbrc.2015.06.153 (2015).Seibold K, Ehrenschwender M (2015) p62 regulates CD40- mediated NFkappaB activation in macrophages through inter- ...
The balance between the membrane-bound a…" [more]doi:10.1016/S0197-4580(04)81871-2James C. PowellBaukje M. ElzingaShu-Chi HsuMaria T. Diaz-MecoJustin V. McCarthyNeurobiology of Aging
p62/SequestosomePar4Th2 polarizationasthmaCell death and differentiation is a monthly research journal focused on the exciting field of programmed cell death and apoptosis. It provides a single accessible source of information for both scientists and clinicians, keeping them up-to-date with advances ...
On the other hand, NF-kappa B plays a key role in SASP. Upon senescence-inducing signals, ATM and ATR block p62-dependent autophagic degradation of GATA4, contributing to NF-kappa B activation and SASP induction.Wang, YujiaWang, LianWen, XiangHao, DanZhang, NanHe, GuJiang, Xian...
(treated with 5 mu M BAY 11-7082) followed by an analysis of the time of autophagy and the multiplicity of the infection of the macrophages, AtgS and Atg12 expressions using real time PCR, the expressions of LC3, P62, NF-kappa B, and mTOR using Western blot, and the IL-6 and IL-...
Knockdown of p62 resulted in reduced colony formation or tumor growth and reduced TRAF6 activation and NF-κB nuclear localization both in vitro and in vivo, thus indicating that p62 sustains NF-κB activation and leukemic cell functions (i.e., cell cycle and myeloid cell development) through ...
Feedback on fat: p62-mTORC1-autophagy connections. Cell 2011, 147, 724–727. [Google Scholar] [CrossRef] [PubMed] [Green Version] Leonard, A.; Millar, M.W.; Slavin, S.A.; Bijli, K.M.; Dionisio Santos, D.A.; Dean, D.A.; Fazal, F.; Rahman, A. Critical role of autophagy...