SAS induced the inhibition of NF-kappa B signaling and apoptosis at least partly via a p62-dependent effect in U251 cells. Collectively, our data shed light on the link between p62 and the NF-kappa B signaling pathway, particularly in glioma cells. The results may facilitate the design of ...
The atypical PKC-interacting protein p62 channels NF-kappa B activation by the IL-1-TRAF6 pathway The atypical protein kinase C (aPKC)-interacting protein, p62, has previously been shown to interact with RIP, linking these kinases to NF-kappaB activation by tumor necrosis factor alpha (TNFalpha...
Especially, pro-inflammatory nuclear factor kappa B (NF kappa B) signaling emanating from CD40-associated TRAF6 appears to be a key pathogenic driving force. Consequently, targeting the CD40-TRAF6 interaction is emerging as a promising therapeutic strategy, but the underlying molecular machinery of ...
Presenilin-1 induces NF-kappa B activation via a RIP-P62-APKC signaling cascadeMembrane-bound chemokines exhibit dual functions as cell adhesion molecules and, after protease-mediated release of their ectodomain, as soluble chemokines. The balance between the membrane-bound a…" [more]...