研究人员通过小鼠胚胎成纤维细胞和两种小鼠模型实验监测了肿瘤发生过程中NF-kB的活性,主要发现癌症发生早期,巨噬细胞(一种先天性免疫细胞)迁移至肿瘤处,肿瘤浸润的巨噬细胞释放的肿瘤坏死因子能促进肿瘤细胞的凋亡,但NF-kB通过调节许多免疫抑制基因,尤其是TGF-beta、IL-10、GM-CSF、G-CSF和VEGF,使肿瘤细胞逃避了这种...
transforming growth factor beta目的探讨肝组织核转录因子-KB(NF-KB)、仅-平滑肌动蛋白(仪-SMA)、转化生长因子(TGF)B1在实验性肝损伤大鼠不同时期的免疫组化表达及其定位情况,探讨其在肝损伤过程中的变化规律及相互关系。方法采用四氯化碳(CCl4)复合因素诱发大鼠肝纤维化模型。50只SPF级sD大鼠随机分为2组:对照组...
3; NAP1; NF kappa B activating protein 1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAB3_HUMAN; TAK1 binding protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3...
2020年7月,朱军研究员在《Cell death and differentiation》杂志在线发表题名为“Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-kappaB-Tgfbeta1 pathway”——卵黄囊起源的PDCD11阳...
摘要: expression and TAK1/MEK and SMAD pathway activation induces pro-survival Mcl-1 expression. These data show that TGF-β-induced NFκB activation is through TAK1/MEK-mediated AKT activation, which is essential for TGF-β to support of osteoclast survival.关键词:...
3; NAP1; NF kappa B activating protein 1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAB3_HUMAN; TAK1 binding protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3...
Curcumin is a natural non-toxic phenol which is isolated from Curcumin longa L Mounting evidence has revealed the anticancer properties of curcumin in various tumors, but the underlying molecular mechanisms of this suppression in cervical cancer is still remained unclear. Here we assessed the antitumor...
et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270, 2008–2011 (1995). Acknowledgements We thank M. L. Schmitz and M. Kracht for plasmids; D. Fahrenkamp for help with the confocal microscope; and B. Lippok for ...
Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within 2022, Frontiers in Pharmacology The Effects of Aerobic Exercise on Oxidative Stress in Older Adults: A Systematic Review and Meta-Analysis 2021, Frontiers in Physiology ...
Amyloid beta peptides also induced an increase in SOD expression levels. This could result from NF-kB activation, as determined by the expression of p65. We observed that the NF-kB inhibitor, PDTC, prevented SOD overexpression after Aβ treatment. Previously we have shown that Aβ peptides ...