transforming growth factor beta目的探讨肝组织核转录因子-KB(NF-KB)、仅-平滑肌动蛋白(仪-SMA)、转化生长因子(TGF)B1在实验性肝损伤大鼠不同时期的免疫组化表达及其定位情况,探讨其在肝损伤过程中的变化规律及相互关系。方法采用四氯化碳(CCl4)复合因素诱发大鼠肝纤维化模型。50只SPF级sD大鼠随机分为2组:对照组...
研究人员通过小鼠胚胎成纤维细胞和两种小鼠模型实验监测了肿瘤发生过程中NF-kB的活性,主要发现癌症发生早期,巨噬细胞(一种先天性免疫细胞)迁移至肿瘤处,肿瘤浸润的巨噬细胞释放的肿瘤坏死因子能促进肿瘤细胞的凋亡,但NF-kB通过调节许多免疫抑制基因,尤其是TGF-beta、IL-10、GM-CSF、G-CSF和VEGF,使肿瘤细胞逃避了这种...
hpd、nlk调控nfkb通路和tgfβ通路及机制研究,nfkb信号通路,tgf beta信号通路,nfkb p65,通路快?br/10e0br/?,wnt信号通路,信号通路,广州通路,通路快递,广东通路 文档格式: .pdf 文档大小: 9.92M 文档页数: 91页 顶/踩数: 0/0 收藏人数: 5 评论次数: ...
TGF-beta/Smad 干细胞与Wnt信号 蛋白酪氨酸激酶 蛋白酶 PI3K/Akt/mTOR 其他 NF-kB 神经信号 微生物Microbiology 代谢 MAPK 膜转运/离子通道 JAK/STAT G蛋白偶联受体&G蛋白 表观遗传学 内分泌与激素 DNA损伤 细胞骨架信号 细胞周期 细胞凋亡 血管生成 抗体(一抗) 标签抗体 内参抗体 抗体相关支持试剂 二抗 单...
目的探讨肝组织核转录因子-KB(NF-KB)、仅-平滑肌动蛋白(仪-SMA)、转化生长因子(TGF)B1在实验性肝损伤大鼠不同时期的免疫组化表达及其定位情况,探讨其在肝损伤过程中的变化规律及相互关系。方法采用四氯化碳(CCl4)复合因素诱发大鼠肝纤维化模型。50只SPF级sD大鼠随机分为2组:对照组20只、造模组(CCl4诱导)30只。
(rs352139), andTGFB1(rs1800469) were not in Hardy-Weinberg equilibrium among the healthy controls. Due to the number of polymorphisms analyzed this is probably a type II error. The polymorphisms do not deviate from Hardy-Weinberg equilibrium when corrected for multiple testing. We cannot ...
Transforming growth factor beta (TGF-β1)/Smad2 signaling pathway plays an important role in the pathogenesis of fibrosis [3]. Obviously, the TGF-β1/Smad2 pathway is the key point for the treatment of anti-lung fibrosis by linking the necessary signaling pathways between inflammation and oxide...
3; NAP1; NF kappa B activating protein 1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAB3_HUMAN; TAK1 binding protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3...
it is known that non-neuronal cell populations are ultimately responsible for maintaining brain homeostasis and neuronal health through neuron-glia and glial cell crosstalk. Many signaling pathways have been proposed to be dysregulated in Alzheimer’s disease, including WNT, TGFβ, p53, mTOR, NFkB,...
4. RT-PCR 通过RNA提取,逆转录和RT-PCR的方法对胰腺组织,IL-1b,TGF-b,Fibronectin,a-SMA,IL-6,TNF-a,RPS6等的mRNA表达水平进行检测. 5. EMSA 将NF-kB探针与细胞核蛋白混合,用抗体标记后进行凝胶电泳,观察探针与蛋白的结合能力. 6. Western Blot 经过提取蛋白,凝胶电泳,转膜,标记一抗和二抗,曝光等步骤...