TGF-beta 1/Smad2NOX4/Nrf(2)Antioxidative stressNF-kBSpecific study about the inhibitory effect of costunolide (CN) and relevant mechanism is of great significance for the treatment of pulmonary fibrosis. Here, the pharmacological activity of costunolide on the treatment of pulmonary fibrosis was ...
研究人员通过小鼠胚胎成纤维细胞和两种小鼠模型实验监测了肿瘤发生过程中NF-kB的活性,主要发现癌症发生早期,巨噬细胞(一种先天性免疫细胞)迁移至肿瘤处,肿瘤浸润的巨噬细胞释放的肿瘤坏死因子能促进肿瘤细胞的凋亡,但NF-kB通过调节许多免疫抑制基因,尤其是TGF-beta、IL-10、GM-CSF、G-CSF和VEGF,使肿瘤细胞逃避了这种...
2020年7月,朱军研究员在《Cell death and differentiation》杂志在线发表题名为“Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-kappaB-Tgfbeta1 pathway”——卵黄囊起源的PDCD11阳...
3; NAP1; NF kappa B activating protein 1; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; TAB3; TAB3_HUMAN; TAK1 binding protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3...
目的:研究氧化低密度脂蛋白(oxidation of low density lipoprotein,Ox-LDL)对肾小球系膜细胞(mesangial cell,MsC)核转录因子kB(nuclear factor-kB,NF-kB)与转化生长因子β1(transforming growth factor-betal,TGF-β1)活性的影响,探讨脂质肾损伤的分子机制。方法:以TGF-β1转录起始位点上游序列构建的报告基因质粒转染...
TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-beta signaling. Sci. Rep. 6, 19070 (2016). Article PubMed PubMed Central CAS Google Scholar Qiu, F., Xiong, J. P., Deng, J. & Xiang, X. J. TRIM29 functions as an oncogene in...
C. Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: Statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. J. Biol. Chem. 283, ...
Myostatin, a transforming growth factor-beta (TGF-) super-family member, has been well characterized as a negative regulator of muscle growth and developme... C Mcfarlane,E Plummer,M Thomas,... - 《Journal of Cellular Physiology》 被引量: 650发表: 2010年 The ubiquitinproteasome pathway is ...
Non-Smad signaling pathways of the TGF-β family 2017, Cold Spring Harbor Perspectives in Biology Signaling cross talk between TGF-β/Smad and other signaling pathways 2017, Cold Spring Harbor Perspectives in Biology Transforming growth factor beta family: Insight into the role of growth factors in...
Gene expression was determined by Real-time qPCR (Applied Biosystems StepOne) in GRX (α-SMA, TGF-β, PPAR-ɣ and PPAR-α) and LX-2 (α-SMA, Col-1(type 1 collagen) and PDGFrβ (platelet-derived growth factor receptor beta) cells treated with methoxyeugenol at 30 μM during 72 h,...