Differential role of an NF-魏B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ Res. 2015;117:166-177. doi: 10.1161/ CIRCRESAHA.117.306666.Milstone, D.S.; Ilyama, M.; Chen, M.; O'Donnell, P.; Davis, V.M.; Plutzky, J.; Brown, J.D.;...
Our 5′ deletion analysis of HOXA9 promoter shows that NF-κB response element is localized within first 400 nucleotides, while minimal basal promoter is within 100 nucleotides upstream of its transcriptional start site. We demonstrate that HOXA9 regulates its own expression by positive feedback ...
Further analyses of IκBα promoter will be necessary to determine which DNA binding domain(s) constitute NO's cis-regulatory element(s). In summary, we have shown that NO can inhibit the activation of NF-κB through the induction and stabilization of its inhibitor, IκBα. The ability of...
DNA element downstream of the kappa B site in the Lcn2 promoter is required for transcriptional activation by I kappa B zeta and NF-kappa B p50 来自 国家科技图书文献中心 喜欢 0 阅读量: 7 作者:Yamazaki,Sumimoto,Kohda 摘要: The nuclear protein I kappa B zeta activates trans ...
Keywords: Activating Transcription Factor 2,Antigens, Surface,biosynthesis,Calcium-Calmodulin-Dependent Protein Kinases,physiology,Cyclic AMP Response Element-Binding Protein,metabolism,E-Selectin,genetics,Endothelium, Vascular,cytology,enzymology,immunology,GTP-Binding Proteins,Humans,JNK Mitogen-Activated Protein ...
Emodin treatment activated the Nuclear factorery throid 2-related factor 2/Kelch-like ECH-associated protein 1-antioxidatant response element (Nrf2/Keap1-ARE) pathway and upregulated the expression of heme oxygenase 1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) in the hepatopancrea...
Also contemplated as an element of the expression cassette is a transcriptional termination site. These elements can serve to enhance message levels and/or to minimize read through from the cassette into other sequences. Origins of Replication In order to propagate a vector in a host cell, it ...
Here, we demonstrate that ADGRG2 is a functional receptor, which in transfected HEK293 cells signals with constitutive activity through the adhesion- and migration-related transcription factors serum response element (SRE) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) ...
sterol regulatory element-binding protein; PD-1, programmed death-1; PD-L1, programmed death- ligand 1; RB, retinoblastoma; CDK4/6, cyclin-dependent kinases 4 and 6; HDAC5, the histone deacetylase member 5; PGE2, prostaglandin E2; IRAK4, L-1R-associated kinase 4; HAS2, hyaluronan synthas...
The results show that an IL-1β-responsive element is located between -300 to -140bp of CCL3 promoter, and -222 to -100bp of CCL4 promoter. As both of these elements contain C/EBPβ motifs, the function of C/EBPβ was examined. IL-1β stimulated the expression of C/EBPβ, and ...